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| CAS No.: | 56341-41-4 |
|---|---|
| Name: | 5-Fluoro-2-oxindole |
| Article Data: | 75 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H6FNO |
| Molecular Weight: | 151.14 |
| Synonyms: | 5-Fluoro-1,3-dihydro-2H-indol-2-one;5-Fluoro-1,3-dihydroindol-2-one;5-Fluoro-2,3-dihydro-2-oxoindole;5-Fluoro-2-oxoindoline;5-Fluoroindolin-2-one;5-Fluoro-1,3-dihydro-indol-2-one; |
| EINECS: | 446-540-4 |
| Density: | 1.311 g/cm3 |
| Melting Point: | 143-147 °C(lit.) |
| Boiling Point: | 307.197 °C at 760 mmHg |
| Flash Point: | 139.588 °C |
| Appearance: | Light Yellow Crystalline |
| Hazard Symbols: |
 Xi,  C
|
| Risk Codes: | 36/37/38-34 |
| Safety: | 22-24/25-45-36/37/322-24/25-45-36/37/39-27-269-27-26 |
| PSA: | 29.10000 |
| LogP: | 1.45830 |
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- 443-69-6
5-fluoro-1H-indole-2,3-dione
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction; | 99.1% |
| With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere; | 87% |
| Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h; Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2; | 81.9% |
- 389571-36-2
5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol; water for 2h; Reagent/catalyst; Temperature; Inert atmosphere; Reflux; | 92.1% |
| Stage #1: 5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester With hydrogenchloride In methanol; water at 80℃; for 5h; Stage #2: With potassium hydroxide In methanol; water at 40℃; for 0.5h; |
| Conditions | Yield |
|---|---|
| With montmorillonite KSF at 20℃; for 1.08333h; Stolle synthesis; Sonication; Neat (no solvent); | 88% |
- 29640-99-1
methyl 2-(5-fluoro-2-nitrophenyl)acetate
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| With iron In acetic acid at 100℃; for 1h; | 87% |
- 18108-55-9
1,3-dihydro-1-hydroxyindole-2-one
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.0833333h; | 81% |
- 283584-52-1
5-fluoro-3-hydrazonoindolin-2-one
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| With sodium ethanolate In ethanol for 5h; Reflux; | 80.4% |
| With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere; | |
| With sodium ethanolate |
| Conditions | Yield |
|---|---|
| With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique; | 78% |
- 29640-98-0
(5-Fluoro-2-nitro-phenyl)-acetic Acid
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| With ammonium formate on silica gel; zinc In carbon dioxide at 50℃; under 90009 Torr; Autoclave; liquid CO2; | 76% |
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| With sodium ethanolate In ethanol for 6h; Reflux; | 73.6% |
- 356068-89-8
(2-amino-5-fluoro-phenyl)-acetic acid hydrazide
- 56341-41-4
5-fluoroindol-2(3H)-one
| Conditions | Yield |
|---|---|
| In water | 73% |
| In water | 73% |
| With hydrogenchloride In water at 20℃; for 12h; pH=3; | 73% |
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Chemistry
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IUPAC Name: 5-Fluoro-1,3-dihydroindol-2-one
Molecular Formula: C8H6FNO
Molecular Weight: 151.14 g/mol
Canonical SMILES: C1C2=C(C=CC(=C2)F)NC1=O
InChI: InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
Product Categories: INDOLE; blocks; FluoroCompounds; IndolesOxindoles; Indole/indoline/oxindole; Indole and Indoline; Heterocycles; Indoles and derivatives; Halides; Pyrroles & Indoles; ketone; Sunitinib; Aromatics Compounds; Intermediate of sunitinib malate; Aromatics; Pyrroles & Indoles; Boronic Acid;Heterocyclic Compounds; Building Blocks; Heterocyclic Building Blocks; Indoles; Fluorinated heterocyclic series
Index of Refraction: 1.56
Molar Refractivity: 37.28 cm3
Molar Volume: 115.2 cm3
Polarizability: 14.78×10-24 cm3
Surface Tension: 41.8 dyne/cm
Density: 1.311 g/cm3
Flash Point: 139.6 °C
Enthalpy of Vaporization: 54.78 kJ/mol
Boiling Point: 307.2 °C at 760 mmHg
Melting Point: 143-147 °C(lit.)
Storage temperature: Keep Cold
Vapour Pressure of 5-Fluorooxindole (CAS NO.56341-41-4): 0.000736 mmHg at 25 °C
Safety Profile
Safty informations of 5-Fluorooxindole (CAS NO.56341-41-4):
Hazard Codes:
Xi
C
Risk Statements: 36/37/38-34
R36/37/38:Irritating to eyes, respiratory system and skin.
R34:Causes burns.
Safety Statements: 22-24/25-45-36/37/39-27-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, KEEP COLD
Specification
5-Fluorooxindole (CAS NO.56341-41-4), its Synonyms are 5-Fluoroindole-2-One ; 5-Fluoro-1,3-dihydro-indol-2-one ; 5-Fluorooxindole 98% . It is light yellow crystalline.