Guerbet Type C-Alkylation of Secondary Alcohols with Primary Alcohols

February 20, 2024

• Title:       

  Guerbet Type C-Alkylation of Secondary Alcohols with Primary Alcohols

• Image Source:

  Nickel-catalyzed guerbet type reaction: C-alkylation of secondary alcohols via double (de)hydrogenation

• Mark:

  Scheme 1

• Associated context:

  This Guerbet type reaction provides an atom- and a step-economical method for the C-alkylation of secondary alcohols under mild, benign conditions (Scheme 1).  Notably, the β-alkylation of secondary alcohols with primary  alcohols has been widely investigated under precious metal  (Ru, Rh, Ir, and Pd) catalysis. In addition to this, seminal  examples based on heterogeneous catalytic systems have been  established for the β-alkylation of secondary alcohols.