Structures of dihydroisomarines, 6-methoxymellein, kigelin and fusarentin ether and their analogues

February 22, 2024

• Title:       

  Structures of dihydroisomarines, 6-methoxymellein, kigelin and fusarentin  ether and their analogues

• Image Source:

  Asymmetric total synthesis of dihydroisocoumarins: 6-methoxymellein, kigelin and fusarentin 6, 7 dimethyl ether by employing proline catalysed asymmetric α-aminoxylation

• Mark:

  Fig. 1

• Associated context:

  The 3,4-dihydroisocoumarin is the fundamental scaffold of  various compounds those possess a wide spectrum of biological  activity [1]. Mellein (1) (pheromone) and its derivatives are most  common 3,4-dihydroisocoumarins and known to exhibit an array  of biological activities. Most of dihydroisocoumarins are isolated  from fungi and plants, mellein (1) [2] was isolated from various  fungi and several insects; it shows fungicidal, antibacterial, and  HCV protease inhibitory activities [3]. The derivatives of mellein, 6-hydroxymellein (2) and 6-methoxymellein (3) were isolated from  phytopathogen, fungi or plant and displayed cytotoxicity, phytotoxicity, and phytoalexin activities [4] (see Fig. 1).