Approaches for the synthesis of O-allylhydroxylamines

February 26, 2024

• Title:       

  Approaches for the synthesis of O-allylhydroxylamines

• Image Source:

  One-Pot Synthesis of O-Allylhydroxylamines through the Organocatalytic Oxidation of Tertiary Allylic Amines Followed by a [2,3]-Meisenheimer Rearrangement

• Mark:

  Scheme 1

• Associated context:

  The past two years, we have been involved in the development of a green, environmentally friendly, organocatalytic oxidation protocol and its application in various transformations. Herein, we present the first organocatalytic one-pot approach  for the synthesis of O-allylhydroxylamines, by utilizing hydrogen peroxide exclusively as the green oxidant (Scheme 1).