Common approaches for 8-hydroxyquinoline synthesis

March 08, 2024

• Title:       

  Common approaches for 8-hydroxyquinoline synthesis

• Image Source:

  Microwave-enhanced Friedl?nder synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria

• Mark:

  Fig. 1a

• Associated context:

  In particular, 8-hydroxyquinolines have seen widespread use in therapeutics, demonstrating an array of medicinal applications (e.g., antibacterial, anti-cancer, anti-neurodegenerative, anti-viral, etc.).  However, many syntheses of novel 8-hydroxyquinoline scaffolds utilize harsh acidic conditions (Fig. 1a) and/or require O-methylated aniline starting materials. These synthetic routes typically suffer from limited substrate scope, involve arduous workups and require deprotection to obtain 8-hydroxyquinolines.