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probucol

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Name

probucol

EINECS 245-560-9
CAS No. 23288-49-5 Density 1.07 g/cm3
PSA N/A LogP N/A
Solubility N/A Melting Point 126-128 °C
Formula C31H48O2S2 Boiling Point 546.7 °C at 760 mmHg
Molecular Weight 516.853 Flash Point 264.9 °C
Transport Information N/A Appearance White Solid
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 23288-49-5 (Probucol) Hazard Symbols N/A
Synonyms

Acetone,bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole (8CI);Phenol, 4,4'-(isopropylidenedithio)bis[2,6-di-tert-butyl-(8CI);4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol];Biphenabid;Bisbid;Bisphenabid;DH 581;Lipomal;Lorelco;Lurselle;NSC 652160;NSC 86225;Panavir;Phenbutol;Probucol;Sinlestal;

Article Data 14

probucol Chemical Properties

Probucol(23288-49-5) is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease.
However, clinical trials were stopped after it was found that it causes long QT syndrome in patients.
Probucol(23288-49-5) was initially developed in the 1970s by a chemical company to maximize airplane tire longevity.
The molecular formula of Probucol is C31H48O2S2 and its formula weight is 516.84.
The density of Probucol(23288-49-5) is 1.07 g/cm3 . The boiling point is  546.7 °C at 760 mmHg. The refractive index is about  1.573. Its flash point is  264.9 °C.
The chemical synonyms of Probucol(23288-49-5) are PROBUCOL;4,4’-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl)-pheno;biphenabid;bisbid;bisphenabid;dh581;4,4'-ISOPROPYLIDINEDITHIO-BIS-(2,6-DI-TERT-BUTYL)PHENOL;4-({1-[(4-hydroxy-3,5-di-t-butylphenyl)thio]-1-methylethyl}thio)-2,6-di-t-butylphenol
The molecular structure of Probucol(23288-49-5):

probucol Uses

Used to lower levels of cholesterol in the blood.

probucol Standards and Recommendations

Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant which inhibits the oxidation of cholesterol in LDLs; this slows the formation of foam cells, which contribute to atherosclerotic plaques.

It is believed to act at ABCA1.

It also lowers levels of HDL.

probucol Specification

Stability
Stable at normal temperatures and pressures.

Decomposition
Carbon monoxide, Carbon dioxide, Sulfur oxides.

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