1218791-07-1Relevant articles and documents
Aerobic Visible-Light-Driven Borylation of Heteroarenes in a Gel Nanoreactor
Herrera-Luna, Jorge C.,Diaz Diaz, David,Abramov, Alex,Encinas, Susana,Jimenez, M. Consuelo,Perez-Ruiz, Raul
supporting information, p. 2320 - 2325 (2021/04/05)
Heteroarene boronate esters constitute valuable intermediates in modern organic synthesis. As building blocks, they can be further applied to the synthesis of new materials, since they can be easily transformed into any other functional group. Efforts toward novel and efficient strategies for their preparation are clearly desirable. Here, we have achieved the borylation of commercially available heteroarene halides under very mild conditions in an easy-to-use gel nanoreactor. Its use of visible light as the energy source at room temperature in photocatalyst-free and aerobic conditions makes this protocol very attractive. The gel network provides an adequate stabilizing microenvironment to support wide substrate scope, including furan, thiophene, selenophene, and pyrrole boronate esters.
A METHOD OF PRODUCING THE KEY INTERMEDIATE OF LAPATINIB SYNTHESIS
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Page/Page column 8, (2014/05/07)
The present invention relates to a production method of the compound of formula I, consisting in coupling the iodo derivative of formula III with boronic acid derivatives, catalyzed by suitable Pd catalysts in a solvent, wherein the boronic acid derivatives are cyclic boronates of the general formula VII, wherein R1, R2, R3 and R4 is H, or a C1-C4 (un)branched alky and wherein X is either a bond or CR5R6 wherein R5 and R6 is H, or a C1-C4 (un)branched alkyl. Other aspects of the invention are cyclic boronates and use of the compound of formula I.
