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1402559-21-0

Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate is a chemical compound with the formula C11H15FN2O2, characterized by the presence of a tert-butyl group, an amino group, and a fluorophenyl group. It is widely recognized in the pharmaceutical industry as a versatile building block for the synthesis of various drugs and biologically active compounds. The unique structural features of Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate make it a valuable component in the design and development of new pharmaceutical agents with enhanced pharmacological properties.

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  • 1402559-21-0 Structure

  • Basic information

    1. Product Name: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate
    2. Synonyms: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate;Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(WXC01007)
    3. CAS NO:1402559-21-0
    4. Molecular Formula: C11H15FN2O2
    5. Molecular Weight: 226.2474032
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1402559-21-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. CAS DataBase Reference: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(1402559-21-0)
    11. EPA Substance Registry System: Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate(1402559-21-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1402559-21-0(Hazardous Substances Data)

1402559-21-0 Usage

Uses

Used in Pharmaceutical Industry:
Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate is used as a key intermediate in the synthesis of various drugs and biologically active compounds. Its presence in the molecular structure allows for the modification of properties such as solubility, stability, and bioavailability, which are crucial for the effectiveness and safety of pharmaceutical agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate is employed as a building block for the design and development of new pharmaceutical agents. Its unique structural features enable the creation of molecules with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Used in Drug Development:
Tert-Butyl (4-Amino-3-Fluorophenyl)Carbamate plays a significant role in drug development, where it is utilized to create novel drug candidates with enhanced therapeutic potential. Its incorporation into the molecular structure of drug candidates allows for the fine-tuning of their pharmacokinetic and pharmacodynamic properties, leading to the development of more effective and safer medications.

Check Digit Verification of cas no

The CAS Registry Mumber 1402559-21-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,2,5,5 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1402559-21:
(9*1)+(8*4)+(7*0)+(6*2)+(5*5)+(4*5)+(3*9)+(2*2)+(1*1)=130
130 % 10 = 0
So 1402559-21-0 is a valid CAS Registry Number.

1402559-21-0Relevant articles and documents

Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer

Wang, Xin,Yu, Chenhua,Wang, Cheng,Ma, Yakun,Wang, Tianqi,Li, Yao,Huang, Zhi,Zhou, Manqian,Sun, Peiqing,Zheng, Jianyu,Yang, Shengyong,Fan, Yan,Xiang, Rong

supporting information, (2019/08/02)

A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) therapy. Structure-activity relationship analysis based on enzymatic and cellular activities led to the discovery of a promising inhibitor 21e. 21e potently inhibited CDK9 with IC50 value of 11 nM and suppressed the stemness properties of NSCLC effectively. It could decrease the stemness phenotypes of NSCLC cells, including tumor sphere formation, side-population and stemness markers abundance. 21e displayed good selectivity over the CDK family kinases and kinase profiling assay against 381 kinases. In addition, 21e inhibited cell proliferation, colony-formation, and cell cycle progression and induced apoptosis in NSCLC. In H1299 xenograft mouse model, a once-daily dose of compound 21e at 20 mg/kg significantly suppressed the tumor growth without obvious toxicity. Studies of mechanisms of action indicated that 21e efficiently inhibited CDK9 signaling pathway and stemness both in vitro and in vivo. Collectively, 21e as a novel CDK9 inhibitor with CSCs inhibition properties could be a promising agent for the treatment of NSCLC.

COMPOUNDS USEFUL AS CSF1 MODULATORS

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Paragraph 00230; 00233; 00234, (2016/04/26)

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

PROTEIN KINASE INHIBITORS

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Page/Page column 52, (2012/10/18)

The present invention relates to novel kinase inhibitors. Compounds of this class have been found to be effective inhibitors of protein kinases; including members of PDGFR and VEGFR families.

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