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4-METHOXY-3-METHYLPHENYLACETONE, commonly known as piperonal, is a versatile chemical compound characterized by its sweet, floral odor. It is widely recognized for its applications in the production of perfumes, flavorings, pharmaceuticals, and as a precursor in the synthesis of various chemical compounds. Piperonal's unique properties also extend to its use in the manufacturing of insecticides and fungicides, highlighting its broad utility across different industries.

16882-23-8

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16882-23-8 Usage

Uses

Used in Perfumery and Flavoring Industry:
4-METHOXY-3-METHYLPHENYLACETONE is used as a fragrance ingredient and flavoring agent for its distinctive sweet, floral scent. It imparts a pleasant aroma to a variety of products, enhancing their sensory appeal and consumer experience.
Used in Pharmaceutical Industry:
As a precursor in the synthesis of pharmaceuticals, 4-METHOXY-3-METHYLPHENYLACETONE plays a crucial role in the development of new drugs. Its chemical properties make it a valuable component in the production of various medicinal compounds, contributing to advancements in healthcare and medicine.
Used in Pesticide Industry:
4-METHOXY-3-METHYLPHENYLACETONE is used as a key component in the manufacturing of insecticides and fungicides. Its effectiveness in controlling pests and fungi makes it an essential ingredient in agricultural and horticultural applications, helping to protect crops and maintain their health.
Used in Illicit Drug Production:
While not a primary intended use, 4-METHOXY-3-METHYLPHENYLACETONE is also utilized in the preparation of illicit drugs such as MDMA (ecstasy) and methamphetamine. Its involvement in the production of these substances highlights the need for strict regulation and control of its distribution and use.
Used in Antimicrobial and Anti-inflammatory Research:
4-METHOXY-3-METHYLPHENYLACETONE has been studied for its potential antimicrobial and anti-inflammatory properties. Its ability to combat microbial infections and reduce inflammation could lead to new therapeutic applications in medicine, further expanding its utility in the healthcare sector.

Check Digit Verification of cas no

The CAS Registry Mumber 16882-23-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,8 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16882-23:
(7*1)+(6*6)+(5*8)+(4*8)+(3*2)+(2*2)+(1*3)=128
128 % 10 = 8
So 16882-23-8 is a valid CAS Registry Number.

16882-23-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-methoxy-3-methylphenyl)propan-2-one

1.2 Other means of identification

Product number -
Other names (3-methyl-4-methoxyphenyl)acetone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16882-23-8 SDS

16882-23-8Synthetic route

2-(4-methoxy-3-methyl-phenyl)-acetoacetonitrile
714258-55-6

2-(4-methoxy-3-methyl-phenyl)-acetoacetonitrile

(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

Conditions
ConditionsYield
With sulfuric acid
(4-methoxy-3-methylphenyl)magnesium bromide
117896-10-3

(4-methoxy-3-methylphenyl)magnesium bromide

chloroacetone
78-95-5

chloroacetone

(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

Conditions
ConditionsYield
2-methylmethoxybenzene
578-58-5

2-methylmethoxybenzene

(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aqueous formaldehyde; aqueous HCl; petroleum ether
3: ethanolic sodium ethylate
4: aqueous H2SO4
View Scheme
3-methyl-4-methoxybenzyl chloride
60736-71-2

3-methyl-4-methoxybenzyl chloride

(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: ethanolic sodium ethylate
3: aqueous H2SO4
View Scheme
2-(4-methoxy-3-methylphenyl)acetonitrile
75391-57-0

2-(4-methoxy-3-methylphenyl)acetonitrile

(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanolic sodium ethylate
2: aqueous H2SO4
View Scheme
1-(4-methoxy-3-methylphenyl)-2-nitroprop-1-ene

1-(4-methoxy-3-methylphenyl)-2-nitroprop-1-ene

(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

Conditions
ConditionsYield
With acetic acid In methanol; dichloromethane; water
(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

2-(4-methoxy-3-methyl-phenyl)-1-methyl-ethylamine
114963-00-7

2-(4-methoxy-3-methyl-phenyl)-1-methyl-ethylamine

Conditions
ConditionsYield
With methanol; ammonia; nickel at 80 - 90℃; under 25742.8 Torr; Hydrogenation;
(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

methylamine
74-89-5

methylamine

[2-(4-methoxy-3-methyl-phenyl)-1-methyl-ethyl]-methyl-amine
827611-22-3

[2-(4-methoxy-3-methyl-phenyl)-1-methyl-ethyl]-methyl-amine

Conditions
ConditionsYield
With methanol; nickel at 90 - 100℃; under 51485.6 Torr; Hydrogenation;
(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

4-(2-Amino-propyl)-2-methyl-phenol

4-(2-Amino-propyl)-2-methyl-phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel; methanol; NH3 / 80 - 90 °C / 25742.8 Torr / Hydrogenation
2: aqueous HBr
View Scheme
(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

2-Methyl-4-(2-methylamino-propyl)-phenol
6036-83-5

2-Methyl-4-(2-methylamino-propyl)-phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel; methanol / 90 - 100 °C / 51485.6 Torr / Hydrogenation
2: aqueous HBr
View Scheme
(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

2-[(aminocarbonyl)amino]-4-methyl-5-(3-methyl-4-methoxyphenyl)-3-thiophenecarboxamide

2-[(aminocarbonyl)amino]-4-methyl-5-(3-methyl-4-methoxyphenyl)-3-thiophenecarboxamide

Conditions
ConditionsYield
(4-methoxy-3-methyl-phenyl)-acetone
16882-23-8

(4-methoxy-3-methyl-phenyl)-acetone

2-amino-1-(3-chloro-phenyl)-ethanol
53360-89-7

2-amino-1-(3-chloro-phenyl)-ethanol

N-[2-(4-methoxy-3-methylphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine

N-[2-(4-methoxy-3-methylphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine

Conditions
ConditionsYield

16882-23-8Relevant articles and documents

Process for producing phenylacetones

-

, (2008/06/13)

A phenylacetone or its derivative having the general formula (I): STR1 wherein X, Y, and Z are independently a hydrogen atom, a hydroxyl group, a halogen atom, a nitro group, an amino group, a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 6 carbon atoms, or a benzyloxy group and any two substituents of X, Y, and Z may form, together with the benzene ring, a heterocycling ring having 5 to 7 members including 1 or 2 oxygen atoms is produced at a high yield and a high selectivity by reacting a 3-phenylpropylene or its derivative having the general formula (II): STR2 wherein X, Y, and Z are as defined above, with an alkyl nitrite having the general formula (III): wherein R is an aliphatic, aromatic, or alicyclic saturated or unsaturated hydrocarbon group in the presence of (a) water, (b) an alcohol, (c) a palladium catalyst, and (d) an optional amine or copper compound, or by reacting the above-mentioned 3-phenylpropylene or its derivative with the above-mentioned alkyl nitrite in the presence of (a) an alcohol, (b) a palladium catalyst and (c) an optional amine or copper compound to form 1-phenyl-2,2-dialkoxypropane or it derivative having the general formula (IV): STR3 wherein X, Y, Z and R are as defined above, followed by hydrolyzing the reaction product.

Secondary amines

-

, (2008/06/13)

Compounds of formula (II): STR1 or salt thereof; wherein R1 is hydrogen or methyl, R2 is hydrogen or methyl, R3 is hydrogen, C1-12 straight or branched alkyl, C3-10 cycloalkyl, phenyl(C1-4)-alkyl or benzyl optionally substituted by C1-4 alkyl, C1-4 alkoxy or halogen; R4 is hydrogen, halogen, hydroxy, C1-4 alkyl or C1-4 alkoxy, R5 is hydrogen or fluorine, R6 is hydrogen or fluorine, R7 is halogen; and n is 1 or 2, have anti-obesity and/or anti-hyperglycaemic activity.

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