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175021-13-3

3-(chloromethyl)cyclobutanone is a cyclic ketone chemical compound with the molecular formula C5H7ClO. It features a chloromethyl group attached to a cyclobutanone ring, and is known for its colorless liquid form with a pungent odor. Due to its hazardous and potentially toxic nature, it requires careful handling and storage, adhering to proper safety protocols.

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  • 175021-13-3 Structure

  • Basic information

    1. Product Name: 3-(chloromethyl)cyclobutanone
    2. Synonyms: 3-(chloromethyl)cyclobutanone;3-(chloromethyl)cyclobutan-1-one
    3. CAS NO:175021-13-3
    4. Molecular Formula: C5H7ClO
    5. Molecular Weight: 118.56148
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 175021-13-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(chloromethyl)cyclobutanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(chloromethyl)cyclobutanone(175021-13-3)
    11. EPA Substance Registry System: 3-(chloromethyl)cyclobutanone(175021-13-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 175021-13-3(Hazardous Substances Data)

175021-13-3 Usage

Uses

Used in Pharmaceutical Industry:
3-(chloromethyl)cyclobutanone serves as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to be a key component in creating a range of medicinal agents.
Used in Organic Synthesis:
As a reagent in organic synthesis, 3-(chloromethyl)cyclobutanone is utilized for its ability to participate in reactions such as nucleophilic substitution and addition reactions. This makes it a valuable tool in the creation of diverse organic molecules for different applications.

Check Digit Verification of cas no

The CAS Registry Mumber 175021-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,0,2 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 175021-13:
(8*1)+(7*7)+(6*5)+(5*0)+(4*2)+(3*1)+(2*1)+(1*3)=103
103 % 10 = 3
So 175021-13-3 is a valid CAS Registry Number.

175021-13-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(chloromethyl)cyclobutan-1-one

1.2 Other means of identification

Product number -
Other names 3-chloromethylcyclobutanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175021-13-3 SDS

175021-13-3Relevant articles and documents

Preparation of 2-Azabicyclo[21.1]hexane Hydrochloride

Liao, Haili,Li, Aimin,Chen, Xingsong,Liang, Kun,Shen, Yang,Liang, Qingfeng,Xu, Kewei,Shore, Daniel G. M.,Villemure, Elisia,Siu, Michael,Huestis, Malcolm P.

, p. 2251 - 2253 (2016)

A batchwise, multigram preparation of 2-azabicyclo-[2.1.1]hexane hydrochloride (1·HCl) was developed, delivering a total of 195 grams of material. The key synthetic step involves an intramolecular displacement of a primary alkyl chloride with a tert-butylsulfinamide to forge the [2.1.1]-bicyclic ring system.

Confining the Χ space of basic natural amino acids: Cyclobutanederived Χ1, Χ2-constrained analogues of arginine, lysine and ornithine

Radchenko, Dmytro S.,Michurin, Oleg M.,Grygorenko, Oleksandr O.,Scheinpflug, Kathi,Dathe, Margitta,Komarov, Igor V.

, p. 505 - 511 (2013)

Four Χ1, Χ2-constrained cyclobutane-derived basic amino acidsdconformationally restricted analogues of arginine, lysine and ornithinedwere prepared as the derivatives properly protected for Fmoc-solid phase peptide synthesis. Compatibility of the synthesi

Synthesis of 2,4-methanoproline analogues via an addition-Intramolecular substitution sequence

Rammeloo, Thomas,Stevens, Christian V.,De Kimpe, Norbert

, p. 6509 - 6513 (2007/10/03)

A new two-step synthetic approach toward 3-(chloromethyl)cyclobutanone is described and used in the synthesis of 2,4-methanoproline analogues. The key step consists of a reversible addition of hydrogen cyanide onto the imines 12 in 50-74% yield under conditions that allow ring closure. 2-Alkyl-2-azabicyclo [2.1.1]hexane-1-carbonitriles 19, synthesized in four steps, can also be converted to the corresponding amines.

A new entry into 2-azabicyclo[2.1.1]hexanes via 3-(chloromethyl)cyclobutanone

Stevens,De Kimpe

, p. 2174 - 2178 (2007/10/03)

2-Azabicyclo[2.1.1]hexanes, which possess the skeleton of 2,4-methanoproline (a naturally occurring insect antifeedant), were synthesized by imination of the previously unknown 3-(chloromethyl)cyclobutanone and subsequent reductive cyclization. The precursor of the latter, 3-oxocyclobutane carboxylic acid, was prepared by two pathways in multigram quantities.

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