50670-76-3Relevant articles and documents
Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES)
Ahmed, Sabbir,James, Karen,Owen, Caroline P.,Patel, Chirag K.
, p. 1343 - 1346 (2002)
We report the initial results of our study into a series of simple 4′-O-sulfamoyl-4-biphenyl based compounds as novel inhibitors of the enzyme estrone sulfatase (ES). The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker inhibitory activity than EMATE or the tricyclic derivative of COUMATE, namely 667-COUMATE. Furthermore, the compounds are observed to be irreversible inhibitors.
Liquid-crystalline rod-coil polymers based on poly(ethylene oxide)s and the influence of the complexation of LiCF3so3 on the liquid-crystalline assembly
Lee, Myongsoo,Oh, Nam-Keun
, p. 1079 - 1086 (1996)
The synthesis and characterization of rod-coil polymers of ethyl 4′-(4′-oxy-4-biphenylcarbonyloxy)-4-biphenylcarboxylate with polyethylene oxide) of three (3-4), seven (7-4), twelve (12-4) and sixteen (16-4) ethylene oxide units, of 4′-(4′-oxy-4-phenylcarbonyloxy)-4-biphenylcarboxylate with poly (ethylene oxide) of sixteen ethylene oxide units (16-3), and of ethyl 4′-oxy-4-biphenylcarboxylate with poly (ethylene oxide) of sixteen ethylene oxide units (16-2) are described. All the rod-coil polymers except 16-2 display a layered smectic mesophase and, in particular, 16-4 shows a microphase-separated morphology. The complexes of 16-4 with up to 0.3 mol of LiCF3SO3 per mol of ethylene oxide units are also prepared. The rod-coil polymer 16-4 exhibits an enantiotropic smectic B (SB) mesophase. The complexes with 0.05 and 0.1 mol of LiCF3SO3, however, exhibit an enantiotropic smectic A (SA) mesophase in addition to an SB phase. In contrast with the complexes with 0.0-0.1 mol of LiCF3SO3, the complexes with 0.2 and 0.3 mol do not exhibit any smectic mesophases; however, they display a cylindrical micellar mesophase.
Iron-Catalyzed Room Temperature Cross-Couplings of Bromophenols with Aryl Grignard Reagents
Xu, Li-Chen,Liu, Kun-Ming,Duan, Xin-Fang
supporting information, p. 5421 - 5427 (2019/11/14)
Herein we report a room temperature Fe-catalyzed coupling reaction of various bromophenols with aryl Grignard reagents, which exhibits a wide substrate scope and high functional group tolerance. For the first time, the combination of simple Fe(acac)3/PBu3/Ti(OEt)4 has been used as an effective catalyst for the biaryl couplings of bromophenols or their Na or K salts with debromination and etherification side reactions being well suppressed. Various biphenols including natural product garcibiphenyl C as well as pharmaceutical diflunisal and its ethyl ester were facilely synthesized using the present protocol. (Figure presented.).
Experimental evidence for the formation of cationic intermediates during iodine(iii)-mediated oxidative dearomatization of phenols
Tang, Ting,Harned, Andrew M.
supporting information, p. 6871 - 6874 (2018/10/02)
Iodine(iii)-based oxidants are commonly used reagents for the oxidative dearomatization of phenols. Having a better understanding of the mechanism through which these reactions proceed is important for designing new iodine(iii)-based reagents, catalysts, and reactions. We have performed a Hammett analysis of the oxidative dearomatization of substituted 4-phenylphenols. This study confirms that iodine(iii)-mediated oxidative dearomatizations likely proceed through cationic phenoxenium ions and not the direct addition of a nucleophile to an iodine-bound phenol intermediate.
NOVEL AZO-BASED DICHROIC DYE, AND LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL ELEMENT COMPRISING THE AZO-BASED DICHROIC DYE
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Paragraph 0087; 0088; 0090, (2017/06/10)
PROBLEM TO BE SOLVED: To provide a novel azo-based dichroic dye having improved solubility with a host liquid crystal while maintaining a high order parameter (S value), and a liquid crystal composition and a liquid crystal element or the like capable of
DICHROIC DYE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL ELEMENT
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Paragraph 0076; 0079, (2017/06/20)
PROBLEM TO BE SOLVED: To provide a new azo-based dichroic dye having a high order parameter (S value) and an absorption maximum wavelength in a long wavelength region, and a liquid crystal composition and a liquid crystal element containing the dye. SOLUT
DICHROIC DYE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL ELEMENT
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Paragraph 0086; 0088, (2017/07/14)
PROBLEM TO BE SOLVED: To provide a novel azo dichroic dye having solubility for practical use while maintaining high contrast order parameter (S value). SOLUTION: There is provided azo dichroic dye represented by the formula (I), where Ar1 to A1 are each independently a substituted/unsubstituted 1,4-phenylene group, a substituted/unsubstituted naphthylene group or a substituted/unsubstituted (E)-cyclohexane-1,4-diyl group, X1 is a direct bond or a bivalent group, L1 is a direct bond or a bivalent group containing no cyclic structure nor azo bond, B1 and B2 are direct bond or bivalent group containing no cyclic structure nor azo bond and Y1 and Y2 are specific general formulae. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPO&INPIT
Strongly Chemiluminescent Acridinium Esters under Neutral Conditions: Synthesis, Properties, Determination, and Theoretical Study
Nakazono, Manabu,Oshikawa, Yuji,Nakamura, Mizuho,Kubota, Hidehiro,Nanbu, Shinkoh
, p. 2450 - 2461 (2017/03/11)
Various novel acridinium ester derivatives having phenyl and biphenyl moieties were synthesized, and their optimal chemiluminescence conditions were investigated. Several strongly chemiluminescent acridinium esters under neutral conditions were found, and then these derivatives were used to detect hydrogen peroxide and glucose. Acridinium esters having strong electron-withdrawing groups such as cyano, methoxycarbonyl, and nitro at the 4-position of the phenyl moiety in phenyl 10-methyl-10λ4-acridine-9-carboxylate trifluoromethanesulfonate salt showed strong chemiluminescence intensities. The chemiluminescence intensity of 3,4-dicyanophenyl 10-methyl-10λ4-acridine-9-carboxylate trifluoromethanesulfonate salt was approximately 100 times stronger than that of phenyl 10-methyl-10λ4-acridine-9-carboxylate trifluoromethanesulfonate salt at pH 7. The linear calibration ranges of hydrogen peroxide and glucose were 0.05-10 mM and 10-2000 μM using 3,4-(dimethoxycarbonyl)phenyl 10-methyl-10λ4-acridine-9-carboxylate trifluoromethanesulfonate salt at pH 7 and pH 7.5, respectively. The proposed chemiluminescence reaction mechanism of acridinium ester via a dioxetanone structure was evaluated via quantum chemical calculation on density functional theory. The proposed mechanism was composed of the nucleophilic addition reaction of hydroperoxide anion, dioxetanone ring formation, and nonadiabatic transition due to spin-orbit coupling around the transition state (TS) to the triplet state (T1) following the decomposition pathway. The TS which appeared in the thermal decomposition would be a rate-determining step for all three processes.
Phosphate and thiophosphate biphenyl analogs as steroid sulfatase inhibitors
Demkowicz, Sebastian,Kozak, Witold,Das?ko, Mateusz,Mas?yk, Maciej,Kubiński, Konrad,Rachon, Janusz
, p. 94 - 104 (2015/04/27)
Preclinical Research In the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straigh
Photo and electrically switchable behavior of azobenzene containing pendant bent-core liquid crystalline polymers
Srinivasan, M. Vijay,Kannan,Roy
, p. 936 - 946 (2013/03/28)
New class of photo and electrically switchable azobenzene containing pendant bent-core liquid crystalline monomers (AZBM 1, 2, and 3) and their polymers (AZBP 1, 2, and 3) are reported. The synthesized precursors, monomers, and polymers were characterized by FT-IR, 1H, and 13C NMR spectroscopy. Thermal stability of polymers was examined by thermogravimetric analysis and revealed stable up to 260 °C. The mesophase transition of monomers and polymers are observed through polarized optical microscopy (POM) and further confirmed by differential scanning calorimetry (DSC). The electrically switching property of monomers and their polymers were studied by electro-optical method. Among the three monomers AZBM 1, 2, and 3, AZBM 1 and 2 exhibit antiferroelectric (AF) switching and AZBM 3 exhibits ferroelectric (F) switching behavior. On the other hand, low molecular weight polymers (AZMP 1, 2, and 3) show weak AF and F switching behavior. The photo-switching properties of bent-core azo polymers are investigated using UV-vis spectroscopy, trans to cis isomerization occurs around 25 s for AZBP-1 and 30 s for AZBP-2 and 3 in chloroform, whereas reverse processes take place around 80 and 90 s.
