89976-43-2Relevant articles and documents
Photoinduced Cross-Coupling of Aryl Iodides with Alkenes
Liu, Yuliang,Li, Haoyu,Chiba, Shunsuke
supporting information, p. 427 - 432 (2021/01/26)
A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes has been developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes is proposed. The method enables iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.
The Pd-catalyzed synthesis of difluoroethyl and difluorovinyl compounds with a chlorodifluoroethyl iodonium salt (CDFI)
Cao, Chengyao Kimmy,Chen, Chao,Ge, Chenxin,Niu, Yaru,Qu, Hongmei
supporting information, (2021/10/01)
Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI). Moreover, the chlorodifluoroeth
Structural optimization of natural product fusaric acid to discover novel T3SS inhibitors of Salmonella
Li, Chaoqun,Li, Zhiying,Lu, Chunhua,Shen, Yuemao,Song, Yuliang,Xu, Guangsen
, p. 72 - 76 (2021/10/27)
Type III secretion system (T3SS) plays a critical role in host cell invasion and pathogenesis of Salmonella. We recently identified the mycotoxin fusaric acid (FA) as a T3SS inhibitor of Salmonella. Herein, twenty-two diphenylsulfane derivatives were desi
Rhenium-Catalyzed Phthalide Synthesis from Benzamides and Aldehydes via C-H Bond Activation
Jia, Bing,Yang, Yunhui,Jin, Xiqing,Mao, Guoliang,Wang, Congyang
supporting information, p. 6259 - 6263 (2019/09/06)
The [4 + 1] annulation of benzamides and aldehydes for phthalide synthesis was achieved via rhenium-catalyzed C-H activation, which demonstrates an unprecedented reaction pattern distinct from those of other transition-metal catalyses. The reaction also features readily available starting materials, a wide scope for both electro-rich and electro-deficient substrates, and the elimination of homoannulation byproducts.
Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions
Sureshbabu, Popuri,Azeez, Sadaf,Muniyappan, Nalluchamy,Sabiah, Shahulhameed,Kandasamy, Jeyakumar
, p. 11823 - 11838 (2019/10/02)
Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.
Cobalt(III)-Catalyzed Directed C-H Allylation
Gensch, Tobias,Vásquez-Céspedes, Suhelen,Yu, Da-Gang,Glorius, Frank
supporting information, p. 3714 - 3717 (2015/08/18)
The cobalt(III)-catalyzed allylation was developed for amide-directed C-H activation of arenes, heteroarenes, and olefins. A variety of allyl sources can be employed to introduce this useful functional group.
Re/Mg bimetallic tandem catalysis for [4+2] annulation of benzamides and alkynes via C-H/N-H functionalization
Tang, Qiuzheng,Xia, Dexin,Jin, Xiqing,Zhang, Qing,Sun, Xiao-Qiang,Wang, Congyang
supporting information, p. 4628 - 4631 (2013/05/21)
A rhenium-magnesium cocatalyzed [4+2] annulation of benzamides and alkynes via C-H/N-H functionalization is described. The reaction features a divergent and high level of diastereoselectivities, which are readily switchable by subtle tuning of reaction conditions. Thus, a wide range of both cis- and trans-3,4-dihydroisoquinolinones is expediently synthesized in a highly atom-economical manner. Moreover, mechanistic studies unraveled a tandem mode of action between rhenium and magnesium in the catalytic cycles.
Cyanomethyl substituted N-Acyl Tryptamines
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Page/Page column 36, (2009/03/07)
The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula I in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and
4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Zhu, Yuping,Olson, Steven H.,Hermanowski-Vosatka, Anne,Mundt, Steven,Shah, Kashmira,Springer, Marty,Thieringer, Rolf,Wright, Samuel,Xiao, Jianying,Zokian, Hratch,Balkovec, James M.
scheme or table, p. 3405 - 3411 (2009/04/07)
4-Methyl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They were active in vitro and in an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relations
Synthesis and redistribution reactions of asymmetric σ-arylplatinum(II) complexes containing 4,7-phenanthroline
Gallasch, David P.,Woodhouse, Susan L.,Rendina, Louis M.
, p. 1288 - 1294 (2007/10/03)
The mononuclear σ-aryl complexes of the type trans -[Pt(σ -C6H4R)(4,7-phen)(PPh3)2] OTf (R=4-CO2SitBuPh2, 4-CONHMe, 3-CO2SitBuPh2, 3-CONHMe; OTf=trifluoromethanesulfonate) containing a monodentate 4,7-phenanthroline (4,7-phen) ligand were prepared by an oxidative addition reaction of an aryl iodide with Pt(PPh3) 4 to yield the key iodoplatinum(II) precursors trans -[PtI(σ-C6H4R)(PPh3) 2], followed by halogen metathesis with one equivalent of 4,7-phen. The reaction of trans -[Pt(σ-C6 H4R)(4,7-phen)(PPh3)2]OTf with labile complexes of the type trans -[Pt(OTf)L2(σ -C6H4R′)] (L=PEt3, R′=H; L=PPh3, R′=4-CO2SitBuPh2 3-CO2SitBuPh2, 3-CONHMe) afforded the asymmetric dinuclear complexes of the type trans -[Pt(σ -C6H4R)L2(μ-4,7-phen)Pt(σ -C6H4R′) L′2](OTf) 2 (L=PPh3, R=4-CO2SitBuPh2, L′=PEt3, R′=H; L=L′=PPh3, R=4-CONHMe, R′ =4-CO2SitBuPh2; R=4-CO2SitBuPh2, R′=3-CONHMe; R=3-CONHMe, R′=3 -CO2SitBuPh2) in which the 4,7-phen acts as a bridging bidentate ligand. The novel dinuclear species undergo an unusual redistribution reaction that is essentially thermoneutral at 298 K. The exchange process involves facile cleavage of a Pt-N bond and the rapid exchange of trans -[PtL2(σ-aryl)] units in the equilibrium mixture.
