- Name
1-PIPERONYLPIPERAZINE
- EINECS250-968-5
- CAS No.
32231-06-4
- Density1.203 g/cm3
- PSA33.73000
- LogP1.08720
- SolubilitySlightly soluble in water
- Melting Point36-40 °C(lit.)
- FormulaC12H16N2O2
- Boiling Point330.5 °C at 760 mmHg
- Molecular Weight220.271
- Flash Point158.4 °C
- Transport InformationN/A
- Appearancewhite to yellow or yellow-brownish cryst. solid
- Safety26-37/39
- Risk Codes36/37/38
- Molecular Structure
- Hazard SymbolsXi
- SynonymsXi
- Article Data15
1-PIPERONYLPIPERAZINE Synthetic route
ConditionsConditions | Yield |
---|
In o-xylene at 150℃; for 30h; Inert atmosphere; Sealed tube; | 81% |
With aluminum (III) chloride; water In acetonitrile at 20℃; Irradiation; | 41% |
1-(1,3-benzodioxol-5-ylmethyl)-4-[(2-nitrophenyl)methyl]piperazine
ConditionsConditions | Yield |
---|
With hydrazine In 1,4-dioxane; water Inert atmosphere; UV-irradiation; | 80% |
ConditionsConditions | Yield |
---|
With palladium 10% on activated carbon; hydrogen In tert-butyl methyl ether at 13 - 18℃; High pressure; | 78% |
ConditionsConditions | Yield |
---|
Stage #1: piperazine; piperazine dihydrochloride In ethanol at 65℃; for 1h; Stage #2: 5-(chloromethyl)-1,3-benzodioxole In ethanol at 78℃; for 2h; | |
benzyl 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carboxylate
ConditionsConditions | Yield |
---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 2h; | |
- 724428-97-1
4-chloro-6-dimethylamino-3-methylisoxazolo[5,4-d]pyrimidine
6-dimethylamino-3-methyl-4-(3,4-methylenedioxybenzylpiperazino)isoxazolo[5,4-d]pyrimidine
ConditionsConditions | Yield |
---|
In tetrahydrofuran Heating; | 99% |
- 1233143-33-3
tert-butyl 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carboxylate
ConditionsConditions | Yield |
---|
With triethylamine In methanol at 20℃; for 1.5h; Inert atmosphere; | 99% |
- 305859-64-7
1-(benzo[d][1,3]dioxol-5-ylmethyl)-4-tosylpiperazine
ConditionsConditions | Yield |
---|
With triethylamine In tetrahydrofuran at 20℃; for 4.5h; Inert atmosphere; | 99% |
C13H16N2O3
ConditionsConditions | Yield |
---|
With hydrogen In methanol at 120℃; under 30003 Torr; for 24h; Autoclave; | 99% |
- 24726-53-2
tetramethyl 2,2'-(1,4-piperazindiyl)dimaleate
ConditionsConditions | Yield |
---|
In N,N-dimethyl-formamide at 20℃; for 1h; | 98% |
1-PIPERONYLPIPERAZINE Chemical Properties
IUPAC Name: 1-(1,3-benzodioxol-5-ylmethyl)piperazine
The MF of 1-PIPERONYLPIPERAZINE(32231-06-4): C
12H
16N
2O
2The MW of 1-PIPERONYLPIPERAZINE(32231-06-4): 220.27
EINECS: 250-968-5
mp: 36-40 °C(lit.)
bp: 147-149 °C at 2 mm Hg(lit.)
Fp: >230 °F
Density: 1.203 g/cm
3 Index of Refraction: 1.577
Appearance: Crystalline mass.
Solubility in water: Very soluble
Categories: Pharmaceutical Raw Materials;Heterocycles;API intermediates;Building Blocks;Heterocyclic Building Blocks;Piperazines
Synonyms: 3,4-METHYLENEDIOXY-1-(N-PIPERAZINYL)-BENZENE;1-PIPERONYLPIPERAZINE;1-[(1,3-BENZODIOXOL-5-YL)METHYL]PIPERAZINE;1-BENZO[1,3]DIOXOL-5-YLMETHYL-PIPERAZINE;1-(3,4-METHYLENEDIOXYBENZYL)PIPERAZINE;1-(3,4-METHYLENDIOXYBENZYL)PIPERAZINE;AKOS BBS-00006443;AKOS B020126
The Structure of 1-PIPERONYLPIPERAZINE(32231-06-4):
1-PIPERONYLPIPERAZINE Toxicity Data With Reference
1. mouse LD50 intraperitoneal 50mg/kg (50mg/kg)
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 555, 1974.
1-PIPERONYLPIPERAZINE Safety Profile
Hazard Codes:
Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
RIDADR: 3259
WGK Germany: 3
RTECS: TM1550000
Hazard Note: Irritant
HazardClass: 8
PackingGroup: II
1-PIPERONYLPIPERAZINE Specification
1. First Aid Measures
Ingestion:
Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice.
Inhalation:
Remove from exposure to fresh air immediately.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes:
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
2. Handling and Storage
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.