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2-amino-5-nitro-1,3-thiazole
Conditions | Yield |
---|---|
With water | 82.8% |
Conditions | Yield |
---|---|
With sulfuric acid |
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid | |
With sulfuric acid; nitric acid | |
Stage #1: 2-thiazolylamine With sulfuric acid at -5℃; for 0.5h; Stage #2: With nitric acid at -10 - 20℃; for 72.4167h; |
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid anschliessend Erhitzen unter Zusatz von H2O; |
N-(2-thiazolyl)-nitramine
2-amino-5-nitro-1,3-thiazole
Conditions | Yield |
---|---|
With sulfuric acid | |
With sulfuric acid |
Conditions | Yield |
---|---|
With hydrogenchloride |
1-dimethylamino-2-nitroethene
thiourea
2-amino-5-nitro-1,3-thiazole
Conditions | Yield |
---|---|
Stage #1: 1-dimethylamino-2-nitroethene With bromine Stage #2: thiourea |
2-amino-5-nitro-1,3-thiazole
2-Fluoro-5-nitro-thiazole
Conditions | Yield |
---|---|
With sodium tetrafluoroborate; t-butylthionitrite In acetonitrile at 25℃; for 5h; other amines; | 100% |
With sodium tetrafluoroborate; t-butylthionitrite In acetonitrile at 25℃; for 5h; | 100% |
With sodium tetrafluoroborate; t-butyl thionitrite In acetonitrile at 25℃; for 5h; | 99% |
2-amino-5-nitro-1,3-thiazole
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 20h; Inert atmosphere; | 97% |
2-amino-5-nitro-1,3-thiazole
18-crown-6 ether
Conditions | Yield |
---|---|
In methanol; benzene | 96% |
The 2-Amino-5-nitrothiazole, with the cas registry number 121-66-4, has the IUPAC name of 5-nitro-1,3-thiazol-2-amine. This is a kind of yellow crystal with little bitter taste, and it is stable chemcially but incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides. Besides, it is soluble in hot water and dilute acid but slightly soluble in water and organic solvents. What's more, its product categories are various, including blocks; NitroCompounds; Thiazoles; Building Blocks; Heterocyclic Building Blocks; Building Blocks; Heterocyclic Building Blocks. As to its usage, it is usually used in producing the intermediate of azo heterocyclic ring dye. While store this chemical, keep it in a dry, cool and well-ventilated place, away from sulfuric acid and nitric acid.
The characteristics of this chemical are as follows: (1)ACD/LogP: 0.83; (2)ACD/LogD (pH 5.5): 0.83; (3)ACD/LogD (pH 7.4): 0.83; (4)ACD/BCF (pH 5.5): 2.52; (5)ACD/BCF (pH 7.4): 2.52; (6)ACD/KOC (pH 5.5): 67.37; (7)ACD/KOC (pH 7.4): 67.38; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 90.19; (12)Index of Refraction: 1.704; (13)Molar Refractivity: 33.51 cm3; (14)Molar Volume: 86.2 cm3; (15)Polarizability: 13.28 ×10-24 cm3; (16)Surface Tension: 90.2 dyne/cm; (17)Density: 1.682 g/cm3; (18)Flash Point: 162.5 °C; (19)Enthalpy of Vaporization: 58.91 kJ/mol; (20)Boiling Point: 345.1 °C at 760 mmHg; (21)Vapour Pressure: 6.32E-05 mmHg at 25°C; (22)Exact Mass: 144.994597; (23)MonoIsotopic Mass: 144.994597; (24)Topological Polar Surface Area: 113; (25)Heavy Atom Count: 9; (26)Complexity: 125.
Use of 2-Amino-5-nitrothiazole: 2-Amino-5-nitrothiazole could react to produce 2-bromo-5-nitro-thiazole, with the following condition: reagent: t-butyl thionitrate, CuBr2; solvent: acetonitrile; reaction time: 4.5 hours; reaction temp.: 25 ℃; yield: 77%.
When deal with this chemical, you should be very cautious. For one thing, it is irritant. It is irritating to eyes, respiratory system and skin and may cause inflammation to the skin or other mucous membranes. For another thing, it is harmful and may cause damage to health. If by inhalation, in contact with skin and if swallowed, it is very dangerous. Then it has the possible risks of irreversible effects. Therefore, you should take the following instructions. Wear suitable protective clothing and gloves. If in case of accident of if you feel unwell, seek medical advice immediately (show the label where possible), and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice. Then remember not to contact with skin and eyes.
In addition, you could obtain the molecular structure by converting the following datas:
(1)Canonical SMILES: C1=C(SC(=N1)N)[N+](=O)[O-]
(2)InChI: InChI=1S/C3H3N3O2S/c4-3-5-1-2(9-3)6(7)8/h1H,(H2,4,5)
(3)InChIKey: MIHADVKEHAFNPG-UHFFFAOYSA-N
Below are the toxicity information of this chemical:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | National Technical Information Service. Vol. AD277-689, |