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Basic information

  • Name:
  • Candesartan

  • CAS No.:
  • 139481-59-7

  • Formula:
  • C24H20N6O3
  • Synonyms:
  • Blopress (TN);Candesartan [USAN:INN];Blopress;CV 11974;2-Ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid;Candesartan (USAN);1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-((2-(1H-tetrazol-5-yl)(1,1-biphenyl)-4-yl)methyl)-;Cyclohexyl-1-Chloro Ethyl Carbamate;
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Chemistry

Molecular structure of Candesartan (CAS NO.139481-59-7) is:

Product Name: Candesartan
CAS Registry Number: 139481-59-7
IUPAC Name: 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
Molecular Weight: 440.454 [g/mol]
Molecular Formula: C24H20N6O3
XLogP3-AA: 4.1
H-Bond Donor: 2
H-Bond Acceptor: 7
Melting Point: 183-185 °C
Surface Tension: 59.6 dyne/cm
Density: 1.41 g/cm3
Flash Point: 410.3 °C
Enthalpy of Vaporization: 115.4 kJ/mol
Boiling Point: 754.8 °C at 760 mmHg
Vapour Pressure: 6.15E-24 mmHg at 25°C
Product Categories: Active Pharmaceutical Ingredients;Candesartan Cilexetil;API intermediates;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Candesartan Cilexatil

Uses

 Candesartan (CAS NO.139481-59-7) is an angiotensin II receptor antagonist. It mainly used for the treatment of hypertension. It can combination with diuretic, Candesartan is available in a combination formulation with a low dose thiazide diuretic, invariably Hydrochlorothiazide, to achieve an additive antihypertensive effect.

Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 20/21/22-36/37/38 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

Specification

 Candesartan , its cas register number is 139481-59-7. It also can be called 2-Ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid ; 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- .It is a crystalline solid.

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