|Name:||2-Butenedioicacid (2E)-, iron(2+) salt (1:1)|
|Synonyms:||Fumafer;Fumiron;Heferol;Ircon;Iron fumarate (Fe(C4H2O4));Iron(II) fumarate;Orgasal;Toleron;Tolferain;Tolifer;Ferrous Fumarate EP Powder;2-Butenedioicacid (E)-, iron(2+) salt (1:1);Fumaric acid, iron(2+) salt (1:1) (8CI);Cpiron;Erco-Fer;Feostat;Feroton;Ferrone;Ferrotemp;Fersamal;|
|Melting Point:||>280 ºC|
|Appearance:||orange red to reddish-brown powder with no odour and no taste|
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Iron is an essential component in the physiological formation of hemoglobin, adequate amounts of which are necessary for effective erythropoiesis and the resultant oxygen transport capacity of the blood. A similar function is provided by iron in myoglobin production. Iron also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Iron is necessary for catecholamine metabolism and the proper functioning of neutrophils
The IUPAC name of Ferrous fumarate is (E)-but-2-enedioate; iron(2+). With the cas register number of 141-01-5, it is a orange red to reddish-brown powder with no odour and no taste. And its product categories are including organic-metal salt; pharmacopoeia (usp); pharmacopoeia a-z; carbonyl compounds; carboxylic acid salts; organic building blocks. This chemical is stable chemicallly.
The characteristics of this chemical are as below: (1)H-Bond Acceptor: 4; (2)Rotatable Bond Count: 0; (3)Exact Mass: 169.930251; (4)MonoIsotopic Mass: 169.930251; (5)Topological Polar Surface Area: 80.3; (6)Heavy Atom Count: 9; (7)Formal Charge: 0; (8)Complexity: 108; (9)Covalently-Bonded Unit Count: 2.
The production method is as following: This chemical is replaced by sodium fumarate with ferrisulphas. Firstly, heat the water till at the boiling point, and add sodium fumarate while stirring, and then add sodium carbonate seperately till the PH value gets 6.5-6.7; Secondly, after well-stirred, filter the chemical and get sodium fumarate solution. Thirdly, add ferrisulphas solution and then have the operation of heating, reflux, cooling and then get the crystal. Lastly, filter cake should be washed with distilled water to comform to required, and then dry to get the Ferrous fumarate, with field of 83%.
The usage of this chemical is as below: Ferrous fumarate could be the food ferrum reinforcer, with the absorbing effect better than inorganic ferrum. It could be used in salt and bonbon, with the usage amount of 1800～3600mg/kg; It could be used in grain with high ferrum and its products, with usage amount of 520~580mg/kg; It could be used in dairy food and baby food, with amount of 180～300mg/kg; It could also be used in frumentum and its products, with the amount of 70～150mg/kg; And its amount in beverage is 30～60mg/kg. When store, you should keep it in cool, dry and well-ventilated room.
You should be cautious while dealing with this chemical: This chemical is irritating to eyes, respiratory system and skin, so you should not breathe dust while using, and remember to wear suitable protective clothing, gloves and eye/face protection .
The following datas could be converted into the molecular structure:
(1)Canonical SMILES: C(=CC(=O)[O-])C(=O)[O-].[Fe+2]
(2)Isomeric SMILES: C(=C/C(=O)[O-])\C(=O)[O-].[Fe+2]
Below are the toxicity information which has been tested:
|Organism||Test Type||Route||Reported Dose (Normalized Dose)||Effect||Source|
|mouse||LD50||intraperitoneal||480mg/kg (480mg/kg)||American Journal of the Medical Sciences. Vol. 241, Pg. 296, 1961. |
|mouse||LD50||oral||1570mg/kg (1570mg/kg)||American Journal of the Medical Sciences. Vol. 241, Pg. 296, 1961. |
|rat||LD50||intraperitoneal||185mg/kg (185mg/kg)||Drugs in Japan Vol. 6, Pg. 683, 1982.|
|rat||LD50||oral||3850mg/kg (3850mg/kg)||Drugs in Japan Vol. 6, Pg. 683, 1982.|
|rat||LD50||subcutaneous||500mg/kg (500mg/kg)||Drugs in Japan Vol. 6, Pg. 683, 1982.|
|women||LDLo||oral||400mg/kg (400mg/kg)||BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: NAUSEA OR VOMITING
|Human Toxicology. Vol. 7, Pg. 281, 1988. |