Basic information
- Name:
Ketorolac
- CAS No.:
74103-06-3
- Molecular Structure:

- Formula:
- C15H13NO3
- Molecular Weight:
- 255.27
- Deleted CAS:
- 66635-83-4
- Synonyms:
- 1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-, (?à)-;1H-Pyrrolizine-1-carboxylicacid, 5-benzoyl-2,3-dihydro-;(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;(+-)-Ketorolac;
- Density:
- 1.398 g/cm3
- Melting Point:
- 160-161 ºC
- Boiling Point:
- 223.7 ºC at 760 mmHg
- Flash Point:
- 89.1 ºC
- Appearance:
- white crystalline or white powder
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Chemistry
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IUPAC Name: 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Molecular Formula: C15H13NO3
Molecular Weight: 255.27 g/mol
SMILES: n12c([C@@H](C(O)=O)CC2)ccc1C(c1ccccc1)=O
InChI: InChI=1/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
Classification Code: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cyclooxygenase Inhibitors; Drug / Therapeutic Agent; Enzyme Inhibitors; Peripheral Nervous System Agents; Sensory System Agents
Product Categories: API's
Index of Refraction: 1.436
Molar Refractivity: 30.52 cm3
Molar Volume: 116.6 cm3
Polarizability: 12.1×10-24 cm3
Surface Tension: 28.4 dyne/cm
Density: 1.398 g/cm3
Flash Point: 89.1 °C
Enthalpy of Vaporization: 46.02 kJ/mol
Boiling Point: 223.7 °C at 760 mmHg
Melting Point: 160-161 °C
Vapour Pressure of Ketorolac (CAS NO.74103-06-3): 0.0947 mmHg at 25 °C
Uses
Ketorolac (CAS NO.74103-06-3) is a non-steroidal anti-inflammatory drug, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. An ophthalmic (i.e., eye-drop) solution of Ketorolac is available and is used to treat eye pain and to relieve the itchiness and burning of seasonal allergies.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 200mg/kg (200mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982. | |
| mouse | LDLo | intraperitoneal | 100mg/kg (100mg/kg) | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982. |
Safety Profile
RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup of Ketorolac (CAS NO.74103-06-3): II
Specification
Ketorolac (CAS NO.74103-06-3), its Synonyms are (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid ; (+-)-Ketorolac ; Ketorolacum ; 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)- .

