Losartan (114798-26-4),Losartan (114798-26-4) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Losartan
CAS No.:
114798-26-4
Molecular Structure:
Formula:
C₂₂H₂₃ClN₆O
Molecular Weight:
422.92
Synonyms:
2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole;DUP 89;1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2-(2H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl]-;[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol;2-Butyl-4-chloro-1-[[2-(1H-tetrazol-5-yl)[1,1-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol;Losartan Base;
Density:
1.35 g/cm³
Melting Point:
183-184 °C
Boiling Point:
682 °C at 760mmHg
Flash Point:
366.3 °C
Appearance:
pale yellow solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety Description:
26-36 Details

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Chemistry

Molecule structure of Losartan (CAS NO.114798-26-4):

IUPAC Name: [2-Butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Molecular Weight: 422.91062 g/mol
Molecular Formula: C₂₂H₂₃ClN₆O
Density: 1.35 g/cm³
Melting Point: 183-184 °C
Boiling Point: 682 °C at 760 mmHg
Flash Point: 366.3 °C
Index of Refraction: 1.68
Molar Refractivity: 118.23 cm³
Molar Volume: 312.5 cm³
Surface Tension: 53.3 dyne/cm
Enthalpy of Vaporization: 105.1 kJ/mol
Vapour Pressure: 1.55E-19 mmHg at 25 °C
H-Bond Donor: 2
H-Bond Acceptor: 5
Rotatable Bond Count: 8
Tautomer Count: 4
Exact Mass: 422.162187
MonoIsotopic Mass: 422.162187
Topological Polar Surface Area: 92.5
Heavy Atom Count: 30
Classification Code: Angiotensin II Type 1 Receptor Blockers; Anti-arrhythmia agents; Antihypertensive agents; Cardiovascular Agents; Drug / Therapeutic Agent; Human Data

Uses

Losartan (CAS NO.114798-26-4) is used mainly to treat high blood pressure (hypertension). Losartan is being researched as a possible drug for marked slowing of aortic enlargement in Marfan and related syndromes.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	7mg/kg/1W-I (7mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE LUNGS, THORAX, OR RESPIRATION: COUGH GASTROINTESTINAL: OTHER CHANGES	Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man	TDLo	oral	17500ug/kg/17 (17.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE	Lancet. Vol. 347, Pg. 471, 1996.
man	TDLo	oral	18mg/kg/13W-I (18mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE	Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man	TDLo	oral	21429ug/kg/30 (21.429mg/kg)		JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997.
man	TDLo	oral	21429ug/kg/30 (21.429mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED LIVER: OTHER CHANGES	JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997.
women	TDLo	oral	42mg/kg/6W-I (42mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Annals of Internal Medicine. Vol. 124, Pg. 775, 1996.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

Specification

Losartan (CAS NO.114798-26-4) is also named as Hyzaar ; DUP 89 ; UNII-JMS50MPO89 ; 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)- . Losartan (CAS NO.114798-26-4) is pale yellow solid.