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Methanesulfonic acid

  • Name Methanesulfonic acid
  • EINECS200-898-6
  • CAS No. 75-75-2
  • Density1.511 g/cm3
  • PSA62.75000
  • LogP0.58480
  • SolubilityMiscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.
  • Melting Point19 °C
  • FormulaCH4O3S
  • Boiling Point167 °C (10 torr)
  • Molecular Weight96.107
  • Flash Point>230 °F
  • Transport InformationUN 3265 8/PG 2
  • Appearancecolourless or light yellow liquid
  • Safety26-36-45-1/2-36/37/39
  • Risk Codes34-22
  • Molecular Structure
    Molecular Structure of 75-75-2 (Methanesulfonic acid)
  • Hazard SymbolsCorrosiveC
  • SynonymsCorrosiveC
  • Article Data152

Methanesulfonic acid Synthetic route

67-56-1

methanol

82220-45-9

methanesulfonic phosphoric anhydride, diisopropyl ester

A

75-75-2

methanesulfonic acid

B

26955-63-5, 129149-78-6

diisopropyl methyl phosphate

Conditions
ConditionsYield
for 1h; Ambient temperature;A 100%
B 98%
74-93-1

methylthiol

75-75-2

methanesulfonic acid

Conditions
ConditionsYield
With dihydrogen peroxide; methanesulfonic acid In water at 40 - 110℃; for 10h;100%
With dihydrogen peroxide In water at 35 - 45℃; for 10h;100%
With nitric acid at 80℃; for 8h; Concentration; Temperature;93.75%
With Mg(2+)*O4V(3-)*C19H42N(1+); dihydrogen peroxide In acetonitrile at 20 - 40℃; for 25h; Reagent/catalyst; Temperature;63.9%
67-56-1

methanol

4972-37-6

methanesulfonic phosphoric anhydride, diethyl ester

A

75-75-2

methanesulfonic acid

B

867-17-4

diethyl methyl phosphate

Conditions
ConditionsYield
for 1h; Ambient temperature;A 91%
B 99%
2386-57-4

methanesulfonic acid sodium salt

75-75-2

methanesulfonic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 40℃; for 3h; Temperature;98.4%
7143-01-3

Methanesulfonic anhydride

75-75-2

methanesulfonic acid

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide at 10 - 50℃; under 60006 - 90009 Torr; for 10h; Inert atmosphere;97%
Product distribution / selectivity;

(1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl methanesulfonate

A

75-75-2

methanesulfonic acid

B

1033736-87-6

C16H10O3S

Conditions
ConditionsYield
In chloroform-d1 for 0.216667h; Photolysis; Inert atmosphere;A 96%
B n/a
34557-54-5

methane

75-75-2

methanesulfonic acid

Conditions
ConditionsYield
With sulfuric acid; alumina; sulfur trioxide; dihydrogen peroxide In water at 50℃; under 21002.1 - 75007.5 Torr; for 3.5h; Reagent/catalyst; Autoclave;95%
With Methyl methanesulfonate; sulfur trioxide In fluorosulphonic acid at 50℃; under 75007.5 Torr; for 10h;93%
With sulfur trioxide at 50℃; under 75007.5 Torr; Autoclave;91%
624-92-0

Dimethyldisulphide

75-75-2

methanesulfonic acid

Conditions
ConditionsYield
With nitric acid at 80℃; for 6h; Temperature;93.8%
With Mg(2+)*O4V(3-)*C19H42N(1+); water; oxygen In acetonitrile at 90℃; under 30003 Torr; for 24h; Reagent/catalyst; Pressure; Temperature; Autoclave;92%
With oxygen In methanol at 30 - 40℃; for 14h; Irradiation;65%
1404369-05-6

1-(methanesulfonoyloxy)-2(1H)-quinolone

A

75-75-2

methanesulfonic acid

Conditions
ConditionsYield
In methanol; water Quantum yield; UV-irradiation; Photolysis;A 90%
B n/a
34557-54-5

methane

A

75-75-2

methanesulfonic acid

B

7143-01-3

Methanesulfonic anhydride

Conditions
ConditionsYield
With sulfuric acid; sulfur trioxide; dihydrogen peroxide at 50℃; under 75007.5 Torr; Large scale;A 82%
B n/a

Methanesulfonic acid Specification

Methanesulfonic acid is a colorless liquid with the chemical formula CH3SO3H. It is the simplest of the alkylsulfonic acids. Salts and esters of methanesulfonic acid are known as mesylates. It is also called  Methanesulphonic acid, methanesulphonic-acid-, Sulfomethane, CCRIS 2783, HSDB 5004.  Methanesulfonic acid is used as an acid catalyst in organic reactions because it is non-volatile, strong acid that is soluble in organic solvents.Methanesulfonic acid toxic is people .It shoule be Keeped  locked up and out of the reach of children.when you use it, you should  wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

Physical properties about Methanesulfonic acid are:
(1)ACD/LogP: -2.087; (2)ACD/LogD (pH 5.5): -5.39; (3)ACD/LogD (pH 7.4): -5.58; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00 ; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3 ; (9)#H bond donors: 1; (10)Index of Refraction: 1.448; (11)Molar Refractivity: 17.019 cm3; (12)Molar Volume: 63.581 cm3; (13)Polarizability: 6.747 10-24cm3; (14)Surface Tension: 53.3790016174316 dyne/cm; (15)Density: 1.512 g/cm3

Preparation of Methanesulfonic acid:
A process for the preparation of methanesulfonic acid comprising reacting sulfite ions within an aqueous system with dimethyl sulfate at an elevated temperature and, subsequently, adding a strong acid, wherein the molar ratio of sulfite ions to dimethyl sulfate is 1.5 to 2.5:1, and the reaction is maintained at said elevated temperature for at least 2 h.

Uses of Methanesulfonic acid:
Methanesulfonic acid may be considered an intermediate compound between sulfuric acid (H2SO4), and methylsulfonylmethane ((CH3)2SO2), effectively replacing an -OH group with a -CH3 group at each step. This pattern can extend no further in either direction without breaking down the -SO2 group. Methanesulfonic acid can be used in the generation of BH3. By reacting methanesulfonic acid with NaBH4 in an aprotic solvent such as THF or DMS, the complex of BH3 and the solvent is formed.

You can still convert the following datas into molecular structure:
(1)InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4);
(2)InChIKey=AFVFQIVMOAPDHO-UHFFFAOYSA-N;
(3)SmilesS(=O)(=O)(C)O;

The toxicity data of Methanesulfonic acid is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin > 2gm/kg (2000mg/kg)   Kodak Company Reports. Vol. 21MAY1971,
quail LD50 oral 1gm/kg (1000mg/kg)   Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
 
rat LC inhalation > 330ppm/6H (330ppm)   Kodak Company Reports. Vol. 21MAY1971,
rat LD50 oral 200mg/kg (200mg/kg)   Kodak Company Reports. Vol. 21MAY1971,

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