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Name N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester
EINECS1592732-453-0
CAS No. 157115-85-0
Density1.202g/cm³
PSA75.71000
LogP1.22820
SolubilityN/A
Melting Point94.0 to 98.0 °C
FormulaC₁₇H₂₂N₂O₄
Boiling Point547.3°Cat760mmHg
Molecular Weight318.373
Flash Point284.8°C
Transport InformationN/A
Appearancewhite powder
Safety
Risk CodesN/A
Molecular Structure
Hazard SymbolsN/A
SynonymsN/A
Article Data1

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Synthetic route

: 623-33-6
glycine ethyl ester hydrochloride

: C18H23NO4

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine In chloroform; N,N-dimethyl-formamide at -5 - 20℃; for 1.5h; Yield given;

: 2752-38-7
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 2: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme

: 103-80-0
phenylacetyl chloride

lead (II)-compound of ethanethiol: lead (II)-compound of ethanethiol

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C 2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme

: 147-85-3
L-proline

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 86 percent / aq. NaOH / 0.25 h / 0 - 4 °C 2: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C 3: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C View Scheme

: 74-89-5
methylamine

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

: N-phenylacetyl-L-prolylglycine methylamine

Conditions

Conditions	Yield
In methanol Ambient temperature;	99%

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

: N-phenylacetyl-L-prolylglycine amide

Conditions

Conditions	Yield
With ammonia In methanol Ambient temperature;	95%

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

: 157115-95-2
N-phenylacetyl-L-prolylglycine

Conditions

Conditions	Yield
With sodium hydroxide for 3h;	89.9%

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

: N-phenylacetyl-L-prolylglycine dimethylamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 89.9 percent / 1 N aq. NaOH / 3 h 2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C 3: dimethylformamide / 0.5 h / -5 °C View Scheme

: 157115-85-0
N-phenylacetyl-L-prolylglycine ethyl ester

: C20H26N2O6

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 89.9 percent / 1 N aq. NaOH / 3 h 2: ethylmorpholine / dimethylformamide / 0.03 h / -10 °C View Scheme

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Chemical Properties

IUPAC Name: Ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
Synonyms of Noopept (CAS NO.157115-85-0): ethyl phenylacetyl-Pro-Gly ; GVS 111 ; GVS-111 ; Glycine, N-(1-(phenylacetyl)-L-prolyl)-, ethyl ester ; Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester
CAS NO: 157115-85-0
Classification Code: Nootropic
Molecular Formula of Noopept (CAS NO.157115-85-0): C₁₇H₂₂N₂O₄
Molecular Weight: 318.3676
Molecular Structure:

Polar Surface Area: 66.92 Å²
Index of Refraction: 1.548
Molar Refractivity: 84.17 cm³
Molar Volume: 264.7 cm³
Surface Tension: 49.7 dyne/cm
Density: 1.202 g/cm³
Flash Point: 284.8 °C
Enthalpy of Vaporization: 82.67 kJ/mol
Boiling Point: 547.3 °C at 760 mmHg
Vapour Pressure: 4.93E-12 mmHg at 25°C

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Uses

Noopept (CAS NO.157115-85-0) is a drug promotion. It is from the drugs and share similar mechanisms of action, racetam family income, but up to 1,000 times higher than the prototype racetam potent drug, piracetam. Animal studies have shown noopept is to protect and enhance neurological test different memory. Unusual is that peptides derived compounds, noopept also showed oral bioavailability and good blood-brain barrier permeability, and human studies have shown promising and the treatment of Alzheimer's disease has a potential application of the results.

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Product Name

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Synthetic route

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Chemical Properties

N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester Uses

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