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N-(9-Fluorenylmethoxycarbonyloxy)succinimide

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Name

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

EINECS 433-520-5
CAS No. 82911-69-1 Density 1.42 g/cm3
PSA 72.91000 LogP 2.95400
Solubility N/A Melting Point 150-153 °C(lit.)
Formula C19H15NO5 Boiling Point 494.3 °C at 760 mmHg
Molecular Weight 337.332 Flash Point 252.7 °C
Transport Information N/A Appearance White powder
Safety 22-24/25-26/37/39-26 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 82911-69-1 (N-(9-Fluorenylmethoxycarbonyloxy)succinimide) Hazard Symbols IrritantXi
Synonyms

9-Fluorenylmethylsuccinimidyl carbonate;2,5-Pyrrolidinedione, 1-(((9H-fluoren-9-ylmethoxy)carbonyl)oxy)-;Fmoc-OSu;N-(9-FluorenylmethoxyCar;(2,5-dioxopyrrolidin-1-yl) 9H-fluoren-9-ylmethyl carbonate;Fmoc-onsu;N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide;Fmoc;N-(9-FluorenylmethoxyCarbonyloxy) Succinimide;N-(9-Fluorenylmethoxycarbonyloxy)-succinimide;Fluoren-9-ylmethyl succinimidyl carbonate;Fmoc-OSu (9-Fluorenylmethyl succinimidyl carbonate);Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 9H-fluoren-9-ylmethyl ester;9-Fluorenylmethyl succinimidyl carbonate;Fmoc-ONSu;N-(9-Fluorenylmethoxycarbonyloxy) Succinimide;9-Fluorenylmethyl N-succinimidyl carbonate;

Article Data 9

N-(9-Fluorenylmethoxycarbonyloxy)succinimide Synthetic route

6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

28920-43-6

(fluorenylmethoxy)carbonyl chloride

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane for 1h; Ambient temperature;96%
With sodium carbonate In water; toluene at 25 - 30℃; for 2h; Reagent/catalyst; Solvent;56.3%
With sodium carbonate In water; acetone for 0.5h; Acylation;
28920-43-6

(fluorenylmethoxy)carbonyl chloride

82911-72-6

dicyclohexylamine salt of N-hydroxysuccinimide

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Conditions
ConditionsYield
In chloroform90%

C16H26N2O3

28920-43-6

(fluorenylmethoxy)carbonyl chloride

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Conditions
ConditionsYield
In chloroform90%
15149-73-2

2,5-dioxopyrrolidin-1-yl carbonochloridate

24324-17-2

9-Fluorenylmethanol

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Conditions
ConditionsYield
With pyridine In dichloromethane for 5h; Ambient temperature;72%
101-83-7

N-cyclohexyl-cyclohexanamine

chromium oxide activated nickel catalyst

chromium oxide activated nickel catalyst

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / acetone
2: 90 percent / CHCl3
View Scheme
56-45-1

L-serin

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

73724-45-5

N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

Conditions
ConditionsYield
With sodium hydrogencarbonate100%
With sodium carbonate In 1,4-dioxane97%
With sodium hydrogencarbonate In water; acetonitrile94%
72-19-5

L-threonine

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

73731-37-0

Fmoc-Thr-OH

Conditions
ConditionsYield
With sodium hydrogencarbonate100%
Stage #1: L-threonine; N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide With sodium carbonate In 1,4-dioxane; water at 20℃; Inert atmosphere;
Stage #2: With hydrogenchloride In water pH=4;
100%
With sodium hydrogencarbonate In acetone97%
5680-80-8

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

82911-78-2

N-[(9-fluorenylmethoxy)carbonyl]-L-serine methyl ester

Conditions
ConditionsYield
Stage #1: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 0.25h;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide In 1,4-dioxane; water at 20℃; for 14h;
100%
Stage #1: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 0.25h;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide In 1,4-dioxane; water at 20℃; for 14h;
100%
Stage #1: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride With sodium hydrogencarbonate In 1,4-dioxane at 20℃; for 0.5h;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide In 1,4-dioxane at 20℃; for 24h;
97%
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

117286-86-9

3-(3-(amino-4-methoxyphenylmethyl)-4-methoxyphenyl)propionic acid

117286-85-8

3-(α-fluoren-9-ylmethoxycarbonylamino-4-methoxybenzyl)-4-methoxyphenylpropionic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide for 1h; Ambient temperature;100%
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

1397-89-3

AmBisome

127970-81-4

3′-N-Fmoc-AmB

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide at 20℃; for 18h;100%
With pyridine In methanol; N,N-dimethyl-formamide at 23℃; for 4h;99%
With pyridine In methanol; N,N-dimethyl-formamide at 20℃; for 12h;95%

N-(9-Fluorenylmethoxycarbonyloxy)succinimide Specification

The 9-Fluorenylmethyl succinimidyl carbonate, with the CAS registry number 82911-69-1, is also known as 2,5-Pyrrolidinedione, 1-(((9H-fluoren-9-ylmethoxy)carbonyl)oxy)-. It belongs to the product categories of Amino Acid Derivatives; Medical Intermediates; Benzocycles; Fluorenes, Flurenones; Pyrrolidines; N-Protecting Reagents; Biochemistry; Condensation & Active Esterification; Fluorenes; Fluorenes & Fluorenones; N-Substituted Maleimides, Succinimides & Phthalimides; N-Substituted Succinimides; Peptide Synthesis; Protective Reagents (Peptide Synthesis); Synthetic Organic Chemistry; Fmoc-Amino Acid Series. Its EINECS registry number is 433-520-5. This chemical's molecular formula is and molecular weight is . Its IUPAC name is called (2,5-dioxopyrrolidin-1-yl) 9H-fluoren-9-ylmethyl carbonate.

Physical properties of 9-Fluorenylmethyl succinimidyl carbonate: (1)ACD/LogP: 2.32; (2)ACD/LogD (pH 5.5): 2.32; (3)ACD/LogD (pH 7.4): 2.32; (4)ACD/BCF (pH 5.5): 33.91; (5)ACD/BCF (pH 7.4): 33.91; (6)ACD/KOC (pH 5.5): 433.51; (7)ACD/KOC (pH 7.4): 433.51; (8)#H bond acceptors: 6; (9)#Freely Rotating Bonds: 5; (10)Index of Refraction: 1.661; (11)Molar Refractivity: 87.47 cm3; (12)Molar Volume: 236.4 cm3; (13)Surface Tension: 66.7 dyne/cm; (14)Density: 1.42 g/cm3; (15)Flash Point: 252.7 °C; (16)Enthalpy of Vaporization: 76.16 kJ/mol; (17)Boiling Point: 494.3 °C at 760 mmHg; (18)Vapour Pressure: 6.55E-10 mmHg at 25°C.

Preparation: this chemical can be prepared by N-hydroxy-succinimide and 9H-fluoren-9-ylmethyl chloroformate. This reaction is a kind of Acylation. It will need reagent Na2CO3 and solvent H2O, acetone. The reaction time is 30 min.

Uses of 9-Fluorenylmethyl succinimidyl carbonate: it can be used to produce N-(9-fluorenylmethyloxycarbonyl)-L-serine methyl ester. This reaction will need reagent aq. sodium hydrogen carbonate and solvent dioxane with reaction time of 10 min. The yield is about 80%.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1CC(=O)N(C1=O)OC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
(2)InChI: InChI=1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2
(3)InChIKey: WMSUFWLPZLCIHP-UHFFFAOYSA-N

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