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Ritodrine hydrochloride
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Name

Ritodrine hydrochloride

 EINECS 245-514-8
CAS No. 23239-51-2 Density 1.213 g/cm3
PSA 72.72000 LogP 3.54490
Solubility N/A Melting Point 192-196 °C
Formula C17H22ClNO3 Boiling Point 512.3 °C at 760 mmHg
Molecular Weight 323.82 Flash Point 175.6 °C
Transport Information N/A Appearance off-white solid
Safety 36 Risk Codes 22
Molecular Structure Molecular Structure of 23239-51-2 (Ritodrine hydrochloride) Hazard Symbols HarmfulXn
Synonyms

Benzenemethanol,4-hydroxy-a-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-,hydrochloride, (aS)-rel-(9CI);Benzenemethanol, 4-hydroxy-a-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, hydrochloride, (R*,S*)-;Benzyl alcohol, p-hydroxy-a-[1-[(p-hydroxyphenethyl)amino]ethyl]-, hydrochloride, erythro- (8CI);DU21220;Miolene;NSC 291565;Pre-Par;Prempar;Ritodrine hydrochloride;Utemerin;Utopar;Yutopar;

 

Ritodrine hydrochloride Chemical Properties

Molecular Structure of Ritodrine hydrochloride (CAS NO.23239-51-2):

IUPAC Name: 4-[2-[[(1R,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol hydrochloride 
Molecular Weight: 323.81448 [g/mol]
Molecular Formula: C17H22ClNO3
H-Bond Donor: 5
H-Bond Acceptor: 4
Density: 1.213 g/cm3
Melting point: 192-196 °C
Boiling point: 512.3 °C at 760 mmHg  
Flash point: 175.6 °C   
Enthalpy of Vaporization: 82.49 kJ/mol
Vapour Pressure: 2.55E-11 mmHg at 25 °C   
Appearance: Off-White Solid 
EINECS: 245-514-8
Product Categories: Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals
Classification Code: Drug / Therapeutic Agent; Human Data; Relaxant [smooth muscle]; Reproductive Effect 

Ritodrine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 128mg/kg (128mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
dog LD50 oral 2458mg/kg (2458mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: CHANGE IN RATE		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
mouse LD50 intramuscular 433mg/kg (433mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
mouse LD50 intraperitoneal 265mg/kg (265mg/kg)   Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985.
mouse LD50 intravenous 69mg/kg (69mg/kg)   Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985.
mouse LD50 oral 687mg/kg (687mg/kg)   Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985.
mouse LD50 subcutaneous 815mg/kg (815mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: CHANGES IN SPLEEN

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 intramuscular 910mg/kg (910mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 intraperitoneal 330mg/kg (330mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LIVER: OTHER CHANGES

BLOOD: CHANGES IN SPLEEN		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 intravenous 83mg/kg (83mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 oral 1840mg/kg (1840mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: OTHER CHANGES		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 subcutaneous 980mg/kg (980mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BLOOD: CHANGES IN SPLEEN		 Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
women TDLo intravenous 14508ug/kg/15 (14.508mg/kg)   British Medical Journal. Vol. 2, Pg. 1194, 1978.

Ritodrine hydrochloride Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Human and experimental teratogen. Human and experimental reproductive effects. Human systemic effects: metabolic acidosis. When heated to decomposition it emits toxic fumes of NOx and HCl.
Hazard Codes: HarmfulXn 
Risk Statements:22
22:Harmful if swallowed 
Safety Statements:36
36:Wear suitable protective clothing
WGK Germany:3
RTECS:DO6524000

Ritodrine hydrochloride Specification

  Ritodrine hydrochloride (CAS NO.23239-51-2), its Synonyms are N-(p-Hydroxyphenethyl)-4-hydroxynorephedrine hydrochloride ; (R*,S*)-4-Hydroxy-alpha-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]benzyl alcohol hydrochloride ; Benzenemethanol, 4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)-, hydrochloride, (R*,S*)- ; Ritodrine HCl .