- Trimeprazine
- TRIMEPRAZINE HYDROCHLORIDE
- Trimeprazine tartrate
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Cas Database |
| Name |
Trimeprazine tartrate |
EINECS | 224-368-9 |
| CAS No. | 4330-99-8 | Density | N/A |
| PSA | 178.62000 | LogP | 6.98140 |
| Solubility | N/A | Melting Point |
153-155oC |
| Formula | 2(C18H22N2S).C4H6O6 | Boiling Point | N/A |
| Molecular Weight | 746.992 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | 36 | Risk Codes | 20/21/22 |
| Molecular Structure |
|
Hazard Symbols | Xn |
| Synonyms |
Alimemazine tartrate; N,N,2-Trimethyl-3-phenothiazin-10-yl-propan-1-amine tartrate |
Article Data | 1 |
Trimeprazine tartrate Synthetic route
- 40055-94-5
cysteamine radical
- 4330-99-8
trimeprazine semitartrate
- 1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1
2C18H22N2S*C4H6O6*2H(1+)
| Conditions | Yield |
|---|---|
| In water Rate constant; pH 6.5, N2O; |
- 68570-60-5
2-hydroxy-ethylsulfanyl
- 4330-99-8
trimeprazine semitartrate
- 1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1
2C18H22N2S*C4H6O6*2H(1+)
| Conditions | Yield |
|---|---|
| In water Rate constant; pH 6.5, N2O; |
- 40055-90-1
2-carboxy-ethylsulfanyl
- 4330-99-8
trimeprazine semitartrate
- 1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1
2C18H22N2S*C4H6O6*2H(1+)
| Conditions | Yield |
|---|---|
| In water Rate constant; pH 6.5, N2O; |
- 15784-30-2
2-amino-2-carboxy-1,1-dimethyl-ethylsulfanyl
- 4330-99-8
trimeprazine semitartrate
- 1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1
2C18H22N2S*C4H6O6*2H(1+)
| Conditions | Yield |
|---|---|
| In water Rate constant; pH 6.5, N2O; |
- 35772-84-0
Cysteine thiyl radical
- 4330-99-8
trimeprazine semitartrate
- 1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1
2C18H22N2S*C4H6O6*2H(1+)
| Conditions | Yield |
|---|---|
| In water Rate constant; pH 6.5 (phosphate puffer), N2O; |
- 40055-99-0
glutathione thiyl radical
- 4330-99-8
trimeprazine semitartrate
- 1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1
2C18H22N2S*C4H6O6*2H(1+)
| Conditions | Yield |
|---|---|
| In water Rate constant; pH 6.5, N2O; |
- 4330-99-8
trimeprazine semitartrate
- 1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1
2C18H22N2S*C4H6O6*2H(1+)
| Conditions | Yield |
|---|---|
| In water pH 6.5; |
- 4330-99-8
trimeprazine semitartrate
| Conditions | Yield |
|---|---|
| With β‐cyclodextrin In phosphate buffer for 1h; pH=6.8; Kinetics; Further Variations:; pH-values; Reagents; UV-irradiation; |
Trimeprazine tartrate Chemical Properties
Molecular Structure:
Molecular Formula: C40H50N4O6S2
Molecular Weight: 746.978200000001
IUPAC Name: (2R,3R)-2,3-Dihydroxybutanedioic acid; N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine
Synonyms of Trimeprazine tartrate (CAS NO.4330-99-8): 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine tartrate (2:1) ; 10H-Phenothiazine-10-propanamine N,N,beta-trimethyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (2:1) ; Alimemazin (RR)-tartrat ; Alimemazine tartrate ; Bayer 1219 ; EINECS 224-368-9 ; Nedeltran ; Panectyl ; RP 6549 ; Repeltin ; SKF 5277 ; Temaril ; Therafene ; Theralen ; Theralene ; UNII-362NW1LD6Z ; Vallergan ; Vanectyl ; Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-, tartrate (2:1)
CAS NO: 4330-99-8
Product Categories: Antipruritic ; Drug / Therapeutic Agent ; Histamine Agents ; Histamine Antagonists ; Histamine H1 Antagonists ; Neurotransmitter Agents
Trimeprazine tartrate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972. | |
| mouse | LD50 | intravenous | 33mg/kg (33mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972. | |
| mouse | LD50 | oral | 300mg/kg (300mg/kg) | Drugs in Japan Vol. 6, Pg. 41, 1982. | |
| rat | LD50 | intraperitoneal | 110mg/kg (110mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972. | |
| rat | LD50 | intravenous | 35mg/kg (35mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972. | |
| rat | LD50 | oral | 210mg/kg (210mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972. |
Trimeprazine tartrate Safety Profile
Hazard Codes of Trimeprazine tartrate (CAS NO.4330-99-8): 
Xn
Risk Statements: 20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36
S36: Wear suitable protective clothing.
RIDADR: 3249
RTECS: SO6475000
HazardClass: 6.1(b)
PackingGroup: III
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