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The molecular structure of Vindesine sulfate (59917-39-4) as follow:
EINECS: 261-984-7
Molecular formula: C43H57N5O11S
Formula weight: 852
Synonyms: 23-amino-o(sup4)-deacetyl-23-demethoxyvincaleukoblastine sulfate ; 23-amino-o(sup4)-deacetyl-23-demethoxy-vincaleukoblastin sulfate ; 3-carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate ; 4-desacetilvinblastina-c-3-carboxamida sulfato ; desacetylvinblastine amide sulfate ; eldesine ; eldisine
Melting point: >250 ℃
Appearance: Amorphous solid
The product categories about vindesine sulfate (59917-39-4) belong to intermediates & fine chemicals; pharmaceuticals.
Vindesine sulfate (59917-39-4) is a synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. It is used as a kind of anticancer drugs and the extensive usage is applied in antineoplastic combined chemotherapy protocols.
mouse | LD50 | intraperitoneal | 3500ug/kg (3.5mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
mouse | LD50 | intravenous | 6300ug/kg (6.3mg/kg) | Journal of Toxicology and Environmental Health. Vol. 1, Pg. 843, 1976. | |
mouse | LD50 | subcutaneous | 6800ug/kg (6.8mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. | |
rat | LD50 | intraperitoneal | 1050ug/kg (1.05mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
rat | LD50 | intravenous | 1920ug/kg (1.92mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: NORMOCYTIC ANEMIA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
rat | LD50 | subcutaneous | 1790ug/kg (1.79mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983. |
Poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.
Hazard codes: Xn Harmful
Risk statements: 40 Limited evidence of a carcinogenic effect.
Safety statements: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.
Vindesine sulfate (59917-39-4) should be stored at 2-8 ℃. As an anticancer drug, the major side effects of it are myelosuppression and neurotoxicity.