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CAS No.: | 101-84-8 |
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Name: | Diphenyl ether |
Article Data: | 393 |
Molecular Structure: | |
Formula: | C12H10O |
Molecular Weight: | 170.211 |
Synonyms: | Phenylether (8CI);1,1'-Oxybis[benzene];Barrel Therm 330;Benzene, phenoxy-;Biphenyl oxide;Chemcryl JK-EB;Diphenyl oxide;NSC 19311;Oxybisbenzene;Phenoxybenzene;Phenyl oxide;Benzene, 1,1'-oxybis-; |
EINECS: | 202-981-2 |
Density: | 1.063 g/cm3 |
Melting Point: | 26 °C |
Boiling Point: | 258.3 °C at 760 mmHg |
Flash Point: | 99.3 °C |
Solubility: | Insoluble in water |
Appearance: | clear pale yellowish liquid after melting |
Hazard Symbols: | N,Xi,T |
Risk Codes: | 51/53-36/37/38-39/23/24/25-23/24/25-36/38 |
Safety: | 60-61-57-37/39-26-45-36/37 |
Transport Information: | UN 3077 9/PG 3 |
PSA: | 9.23000 |
LogP: | 3.47890 |
tetraphenyl-bismuth trifluoroacetate
diphenylether
Conditions | Yield |
---|---|
With phenol In benzene refluxing overnight (Ar); t.l.c.; | 100% |
In benzene 24 h at 80°C; filtn., evapn., addn. of Cl3CCO2H in CH2Cl2, reflux for 2 h, cooling, washing, drying, t.l.c.; | 38% |
With water In water; benzene 24 h at 80°C, addn. of water; filtn., evapn., addn. of Cl3CCO2H in CH2Cl2, reflux for 2 h, cooling, washing, drying., t.l.c.; | 34% |
Conditions | Yield |
---|---|
With copper(I) oxide; caesium carbonate; hydroxybenzaldoxime; 3 A molecular sieve In acetonitrile at 82℃; for 24h; Ullmann-type coupling; | 100% |
With caesium carbonate; copper(I) oxide; trans-N,N'-bis(pyridin-2-ylmethylene)cyclohexane-1,2-diamine In acetonitrile at 82℃; for 24h; Conversion of starting material; activated 3 A molecular sieve (KnNa12-n[(AlO2)12(SiO2)12]); | 100% |
Stage #1: phenol With caesium carbonate; copper(I) oxide; trans-N,N'-bis(pyridin-2-ylmethylene)cyclohexane-1,2-diamine at 100℃; Molecular sieve 3 Å; Stage #2: iodobenzene In acetonitrile at 82℃; for 24h; | 100% |
Conditions | Yield |
---|---|
In benzene Heating; | 100% |
In benzene at 80℃; for 12h; | 100% |
diphenylether
Conditions | Yield |
---|---|
With dihydrogen peroxide In tetrahydrofuran for 3h; Heating; | 100% |
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; Raney Ni-Al alloy In 1,4-dioxane at 110℃; for 24h; | 99% |
With caesium carbonate; copper(l) iodide In N,N-dimethyl-formamide at 110℃; for 18h; Ullmann condensation; | 98% |
With 2-[(dimethylamino)methyl]-1-thiophenolato-copper(I); caesium carbonate In 1-methyl-pyrrolidin-2-one at 160℃; for 16h; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With C60H48BP3Pd; potassium formate; [2.2.2]cryptande In tetrahydrofuran at 60℃; for 72h; Schlenk technique; Inert atmosphere; | 99% |
With N-tert-butylaminoborane; palladium on activated charcoal In methanol at 20℃; for 120h; | 82% |
With tributyl-amine; tetrabutylammonium tetrafluoroborate In acetonitrile at 20℃; for 1.8h; Inert atmosphere; Electrolysis; | 80% |
With C8K In tetrahydrofuran Product distribution; Ambient temperature; | |
With N-ethyl-N,N-diisopropylamine In acetonitrile for 16h; Irradiation; | 95 %Spectr. |
4-phenoxyphenyl 4-methylbenzenesulfonate
diphenylether
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In methanol; chloroform ice-cooling; | 94% |
With sodium tetrahydroborate; bis(triphenylphosphine)nickel(II) chloride; tricyclohexylphosphine In tetrahydrofuran at 60℃; for 14h; | 70% |
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one at 120℃; for 5h; Ullmann diaryl etherification; Inert atmosphere; | 93% |
With 1-butyl-3-methylimidazolium Tetrafluoroborate; copper(l) chloride at 100℃; for 10h; | 72% |
With copper at 180 - 190℃; | |
With copper at 210 - 230℃; |
Conditions | Yield |
---|---|
With 1-methyl-pyrrolidin-2-one at 120℃; for 4h; Ullmann diaryl etherification; Inert atmosphere; | 93% |
With 1-butyl-3-methylimidazolium Tetrafluoroborate; copper(l) chloride at 100℃; | 82% |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 50℃; for 6h; | 93% |
Diphenyl ether(CAS NO.101-84-8) and many of its properties were first reported as early as 1901.
Diphenyl ether and many of its properties were first reported as early as 1901.It is synthesized by a modification of the Williamson ether synthesis, here the reaction of phenol and bromobenzene in the presence of base and a catalytic amount of copper:
PhONa + PhBr → PhOPh + NaBr
Involving similar reactions, diphenyl ether is a significant side product in the high-pressure hydrolysis of chlorobenzene in the production of phenol
The Diphenyl ether with CAS registry number of 101-84-8 is also known as Benzene, phenoxy-. The IUPAC name is Phenoxybenzene. It belongs to product categories of Pharmaceutical Intermediates; Fine Chemical & Intermediates; Organics; Biphenyl & Diphenyl ether. Its EINECS registry number is 202-981-2. In addition, the formula is C12H10O and the molecular weight is 170.21. This chemical is a clear pale yellowish liquid after melting and insoluble in water. It should be sealed in ventilated and dry place away from fire, heat, oxidants. What's more, it can be used as heat transfer medium and used for organic synthesis, manufacture of perfume and dyes.
Physical properties about Diphenyl ether are: (1)ACD/LogP: 4.21; (2)ACD/LogD (pH 5.5): 4.21; (3)ACD/LogD (pH 7.4): 4.21; (4)ACD/BCF (pH 5.5): 932.39; (5)ACD/BCF (pH 7.4): 932.39; (6)ACD/KOC (pH 5.5): 4647.71; (7)ACD/KOC (pH 7.4): 4647.71; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.572; (11)Molar Refractivity: 52.69 cm3; (12)Molar Volume: 160 cm3; (13)Surface Tension: 38.4 dyne/cm; (14)Density: 1.063 g/cm3; (15)Flash Point: 99.3 °C; (16)Enthalpy of Vaporization: 47.59 kJ/mol; (17)Boiling Point: 258.3 °C at 760 mmHg; (18)Vapour Pressure: 0.0223 mmHg at 25 °C.
Preparation of Diphenyl ether: it is prepared by condensation reaction of chlorobenzene and phenol. The reaction needs catalyst copper and solvent caustic solution. When the reaction is complete, reactant is dealed with acid and the ether oil is vacuum distilled to obtain product.
(1) C6H5OH + NaOH → C6H5ONa + H2O
(2) C6H5ONa + C6H5Cl → C6H5OC6H5 + NaCl
Uses of Diphenyl ether: it is used to produce 4-phenoxy-benzaldehyde by reaction with tris(diformylamino)methane. The reaction occurs with reagent AlCl3 and solvent 1,2-dichloro-ethane at -13 - 1 °C for 16 hours. The yield is about 20%.
When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. There is danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. It also is toxic to aquatic organisms that may cause long-term adverse effects in the aquatic environment. During using it, wear suitable protective clothing, gloves and eye/face protection. Avoid release to the environment and use appropriate containment to avoid environmental contamination. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell seek medical advice immediately. This material and its container must be disposed of as hazardous waste.
You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=CC=C(C=C1)OC2=CC=CC=C2
2. InChI: InChI=1S/C12H10O/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10H
3. InChIKey: USIUVYZYUHIAEV-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rabbit | LD50 | skin | > 7940mg/kg (7940mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | National Technical Information Service. Vol. 0TS0518143, |
rat | LD50 | oral | 2450mg/kg (2450mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: OTHER CHANGES | National Technical Information Service. Vol. 0TS0518143, |