Reference

Antifungal activity of four tetracycline analogs against Candida albicans in vitro: potentiation by amphotericin B

Antifungal activity of four tetracycline analogs against Candida albicans in vitro: potentiation by amphotericin B. Lew, Michael A.; Beckett, Kevin M.; Levin, Myron J. (Div. Clin. Microbiol., Sidney Farber Cancer Inst., Boston, Mass., USA). J. Infect. Dis., 136(2), 263-70 (English) 1977. CODEN: JIDIAQ. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The antifungal activities of 4 tetracyclines in combination with amphotericin B (I) [1397-89-3] were detd. against 20 strains of C. albicans. When a microtiter checkerboard technique was used, minocycline [10118-90-8] (.ltoreq.10 .mu.g/mL) acted synergistically with I against all strains, whereas doxycycline hyclate [24390-14-5] had a reduced effect, and demeclocycline [127-33-3] and tetracycline [60-54-8] had no potentiating effect at this concn. Killing-curve expts. with 2 strains of C. albicans demonstrated that the combination of minocycline and I produced a decrease in no. of colony-forming units of >2 logs in 4 h and a 4-log decrease in 24 h at concns. (minocycline, 0.64 .mu.g/mL; I, 0.1 .mu.g/mL) that were subinhibitory when each agent was used alone. The killing-curve technique indicated that doxycycline had an intermediate degree of synergistic activity, whereas tetracycline had no synergistic activity at clin. relevant concns.

Doxycycline capsules

Doxycycline capsules. Struengmann, A. (Distributa S. A., Luxembourg). Belg. BE 897510 A2 1 Dec 1983, 9 pp. (Dutch). (Belgium). CODEN: BEXXAL. ICI: A61; A61. APPLICATION: BE 21-335 10 Aug 1983. PRIORITY: LU 82-84526 10 Dec 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Sucrose [57-50-1]-corn starch [9005-25-8] pellets are sprayed with a mixt. of doxycycline-HCl.0.5 EtOH.H2O (I) [24390-14-5] and PVP [9003-39-8] until the ratio of doxycycline [564-25-0] to pellets is about 0.7:1, coated with Eudragit E [24938-16-7] dried, and used for filling capsules. For example, a soln. of sucrose 50.0 and corn starch 25.0 in water 10 kg was sprayed onto 25.0 kg cryst. sucrose at 80° and the resulting pellets, after drying, were sieved to sep. the 0.5-0.65 mm fraction. The homogeneous mixt. of 115.4 kg I, PVP, and acetone was sprayed to 37.7 kg pellets, and the pellets were then coated with a 12.There are some commonly used reagents with their cas registry numbers 564-25-0 and 57-50-1 in this article.5% suspension of talc in Eudragit E-100, dried, and dispensed into hard gelatin capsules. The capsule content consisted of I 230.80, sucrose 62.25, corn starch 20.75, talc 5.20, Eudragit E-100 6.40, and PVP 4.60 mg. .