Reference

Coexistence of GABAA and GABAB receptors on Ad and C primary afferents

Coexistence of GABAA and GABAB receptors on Ad and C primary afferents. Desarmenien, Michel; Feltz, Paul; Occhipinti, Guiseppe; Santangelo, Francesca; Schlicter, Remy (Inst. Physiol. Chim. Biol., Strasbourg 67084, Fr.).Chemicals with cas numbers 56-12-2 and 7440-70-2 also play role. Br. J. Pharmacol., 81(2), 327-33 (English) 1984. CODEN: BJPCBM. ISSN: 0007-1188. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Intracellular recordings from adult rat dorsal root ganglion neurons were performed in vitro, and the coexistence of 2 GABA [56-12-2] receptors on the membrane of identified Ad and C primary afferents was demonstrated. Transient applications of GABA (10-6-10-2M) evoked dose-dependent depolarizations and increased membrane conductance. The responses were mimicked by muscimol [2763-96-4], isoguvacine [64603-90-3], THIP [64603-91-4], and 3-aminopropanesulfonic acid [3687-18-1]; they were blocked by bicuculline and picrotoxin. Pentobarbitone increased GABA-induced depolarizations. Perfusion of tetraethylammonium (7.5 mM) and intracellular injection of Cs+ unmasked the Ca2+ component of action potentials, which appeared as long-lasting plateau depolarizations. Such action potentials were shortened in the presence of D600 (5 ′ 10-6-10-5M) and in a medium without Ca2+. Prolonged (5-10 min) perfusion of GABA (10-9-10-5M) shortened the Ca2+ component of action potentials. This effect was mimicked by baclofen [1134-47-0] (10-7-5 ′ 10-6M) and muscimol (5 ′ 10-7-10-5M) and was not affected by bicuculline perfusion (5 ′ 10-6-10-5M). Isoguvacine (2.5 ′ 10-5M) did not affect action potential duration. Two GABA receptors apparently coexist on the membrane of slow conducting primary afferents: the bicuculline-sensitive GABAA receptor mediates depolarizations and the bicuculline-insensitive GABAB receptor shortens the Ca component of action potentials. .

Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods

Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods. Starosciak, Bohdan; Pachecka, Jan; Dobrzanski, Wladyslaw T.; Bicz, Wlodzimierz (Zakl. Mikrobiol. Farm., Akad. Med., Warsaw 02-007, Pol.). Farm.Several substances with their cas registry numbers 738-70-5 and 59-66-5 may be metioned in this study. Pol., 39(7), 399-402 (Polish) 1983. CODEN: FAPOA4. ISSN: 0014-8261. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) No mutagenic activity of astmopent [5874-97-5], Baclofen [1134-47-0], binazine [3778-76-5], chirurcoll [25154-80-7], chlorpropamide [94-20-2], clonazepam [1622-61-3], craviten [55769-64-7], diuramide [59-66-5], furosemide [54-31-9], glafenine [3820-67-5], mirenil [2376-43-4], sadamine [437-74-1], and salbutamol [18559-94-9] was obsd. in the microbial tests used. Metronidazole [443-48-1], biseptol [8064-90-2], trimethoprim [738-70-5], and butapirazole [50-33-9] were mutagenic, the latter, however, only at high concns. .