Reference

Hexafluoroisobutene and/or hexafluorobutene

Hexafluoroisobutene and/or hexafluorobutene. Ohsaka, Yohnosuke; Aminoto, Yoshio; Takagi, Shoji (Daikin Kogyo Co., Ltd. , Japan). Brit. UK Pat. Appl. GB 2119800 A1 23 Nov 1983, 3 pp. (English). (United Kingdom). CODEN: BAXXDU. CLASS: IC: C07C021-18; C07C017-26. APPLICATION: GB 83-12572 6 May 1983. PRIORITY: JP 82-77965 10 May 1982.Several substances with their cas registry numbers 382-10-5 and 74-83-9 may be metioned in this study. DOCUMENT TYPE: Patent CA Section: 35 (Chemistry of Synthetic High Polymers) (CF3)2C:CH2 (I) [382-10-5] and/or CF3CF2CF:CH2 (II) [374-39-0] are prepd. by treating CF3CF:CF2 (III) [116-15-4] with Me halide at 400-800°. Thus, a mixt. of 20 mL/min III and 20 mL/min MeCl [74-87-3] was charged to a reactor for 5 h to give 46 g product mixt. contg. 37.5% I and 15.8% II. .

Hexafluoropropylene (CAS no

Hexafluoropropylene (CAS no. 116-15-4). (European Centre for Ecotoxicology and Toxicology of Chemicals, Belg.). JACC, 48, i-v, 1-67 (English) 2005. CODEN: JACCCH. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) Section cross-reference(s): 59 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chems. (JACC) program. It presents a crit. evaluation of data on the toxicity and ecotoxicity, and environmental fate and impact of hexafluoropropylene (HFP). A hazard/risk assessment is required under current OECD/EU schemes. In the USA, HFP is included in the EPA (Environmental Protection Agency) Chem. Right-to-Know Initiative. HFP is a chem. intermediate used in the synthesis of fluoropolymers, fluoro-elastomers and also fluorinated oils and greases. It is a colorless gas that is only slightly sol. in water. Any HFP released to the environment will be found mainly in the air, where it will be broken down by reaction with hydroxyl radicals to trifluoroacetic acid, hydrogen fluoride and carbon dioxide. HFP is unlikely to bioaccumulate. The environmental risk from exposure is low, since only a small amt. is released into the environment. HFP does not deplete the stratospheric ozone layer. The global warming impact of HFP is insignificant, other than by contributing to carbon dioxide concns. on atm. breakdown. HFP has a low acute toxicity in lab. animals. In repeated exposure studies, the kidney was the principal target organ, as manifest by an increase in relative kidney wt. In one study, there was also a decrease in relative spleen wt. Although no std. reproductive or developmental toxicity studies have been conducted, the reproductive system does not appear to be a target of HFP toxicity and it is not considered that there is a need for any further studies of these end-points. Genotoxicity studies have generally been neg., suggesting a low level of concern. However, recent findings with the structurally related tetrafluoroethylene of chronic toxicity, including certain tumors in life-time studies in mice and rats at high exposure levels, may indicate the possibility of carcinogenicity for HFP. HFP is manufd. in closed systems and occupational exposure, limited to specific job classifications, is expected to be low. It is thus considered to be of low potential risk. Company internal occupational exposure limits range from 0.5 to 2 ppm (3-12 mg/m3). There is no known direct consumer exposure to HFP. Consumer exposure is negligible, arising only from low levels of residual monomer in end-use polymeric products.