Reference

An unexpected reaction of trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) with imidazoles

All Rights Reserved. An unexpected reaction of trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) with imidazoles. Formation of N-difluoromethylthioureas. Xu, Wei; Abboud, Khalil A.; Ghiviriga, Ion; Dolbier, William R., Jr.; Rapp, Magdalena; Wnuk, Stanislaw F.Several reagents with their cas registry numbers 120801-75-4 and 917876-71-2 are used here. (Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA). Organic Letters, 8(24), 5549-5551 (English) 2006 American Chemical Society. CODEN: ORLEF7. ISSN: 1523-7060. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 33 A new reaction of the efficient difluorocarbene-generating reagent trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) was reported in which mols. contg. an N-alkylimidazole or benzimidazole structure underwent an unexpected one-pot conversion to N-difluoromethylthioureas, e.g., I (R = H, MeO or Cl). .