CAS No.1264-72-8,Colistin sulfate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	1264-72-8
Name:	Colistin sulfate

Formula:	2(C52H98N16O13).5(H2SO4)
Molecular Weight:	1253.51000
Synonyms:	NSC 248648;N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;Belcomycin;Polymyxin E sulfate;Colomycin; Colomycin syrup;
EINECS:	215-034-3
Density:	==
Melting Point:	200-220 °C
Boiling Point:	1537.3 °C at 760 mmHg
Flash Point:	883.5 °C
Solubility:	Soluble in water
Appearance:	Powder
Hazard Symbols:	T
Risk Codes:	25
Safety:	45
PSA:	573.64000
LogP:	1.96320

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Standards and Recommendations

Enterprise Standard:

Content≥98.0%

Specification

The Colistin sulfate, with the CAS registry number 408332-79-6, is also known as Belcomycin. It belongs to the product categories of Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Veterinaries. Its EINECS number is 215-034-3. What's more, its systematic name is N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate. Its classification code is Antibacterial. It is a cyclic polypeptide antibiotic from Bacillus colistinus. Colistin sulfate may be used to treat intestinal infections, or to suppress colonic flora. Colistin sulfate is also used as topical creams, powders, and otic solutions. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides. It should be ensured that the workshop is well ventilated or equipped with exhaust devices.

When you are using this chemical, please be cautious about it as the following:
This chemical is toxic if swallowed. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1
(2)Smiles: N1[C@H](C(NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C1=O)CCN)=O)CCN)CC(C)C)CC(C)C)CCN)NC([C@@H](NC(=O)[C@H]([C@H](O)C)NC([C@@H](NC(=O)CCCC[C@@H](CC)C)CCN)=O)CCN)=O)=O)[C@H](O)C.S(O)(O)(=O)=O

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	subcutaneous	58mg/kg (58mg/kg)		Chemotherapy Vol. 16, Pg. 105, 1968.
mouse	LD50	intraperitoneal	21800ug/kg (21.8mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961.
mouse	LD50	intravenous	6mg/kg (6mg/kg)		Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.
mouse	LD50	oral	793mg/kg (793mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961.
mouse	LD50	subcutaneous	53500ug/kg (53.5mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 395, 1961.
rat	LD50	intraperitoneal	10572ug/kg (10.572mg/kg)		Antibiotics Annual. Vol. 7, Pg. 61, 1959/1960.
rat	LD50	oral	121mg/kg (121mg/kg)		Antibiotics Annual. Vol. 7, Pg. 61, 1959/1960.
rat	LD50	subcutaneous	72200ug/kg (72.2mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 7, 1979.