Reference

The activity of polymyxins against Escherichia coli in an in-vitro model of the urinary bladder

The activity of polymyxins against Escherichia coli in an in-vitro model of the urinary bladder. Greenwood, D.; O'Grady, F. (City Hosp., Univ. Nottingham, Nottingham, Engl.). J. Med. Microbiol., 10(2), 255-9 (English) 1977. CODEN: JMMIAV. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Polymyxin B sulfate [1405-20-5] and colistin sulfate [1264-72-8] inhibited E. coli growth under in vitro conditions in a model system simulating conditions in the urinary bladder, with the latter compd. appearing to be more active. Although bacterial growth could be suppressed at clin. achievable levels, drug activity in the simulated therapeutic situation was less than that against exponentially growing cultures in a static system. The differing susceptibilities of the 2 systems probably result from differences in the metabolic states of the cultures, including the lipid compn. of the membrane target of the polymyxins. No phenotypic resistance emerged in the model system, suggesting that such resistance was due to selection of a preexisting fraction of the population which tended to be suppressed by the hydrokinetic washout effect of the model. The sulfomethyl derivs., sulfomyxin sodium [58253-07-9] and colistin sulfomethate sodium [8068-28-8], had little effect on bacterial growth in the model system.

Colistin pesticide

Colistin pesticide. Kono, Shoichi; Hasuda, Katsumi; Koyama, Yasuo; Mihashi, Susumu; Sakurai, Hisashi (Kayaku Antibiotics Research Co., Ltd., Japan). Japan. Kokai JP 52154521 22 Dec 1977 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A01N009-00. APPLICATION: JP 76-70284 15 Jun 1976. DOCUMENT TYPE: Patent CA Section: 5 (Agrochemicals) Colistin [1066-17-7] or its salts are microbiocides and insecticides. Thus, colistin sulfate [1264-72-8] at 50 ppm controlled Pseudomonas lachrymus infection in cucumber.