Reference

Effect of chronic administration of fenibut and diazepam on GABA and benzodiazepine receptors in mouse brain

Effect of chronic administration of fenibut and diazepam on GABA and benzodiazepine receptors in mouse brain. Rago, L.; Sarv, H.In this study， 56-12-2 and 12794-10-4 are also used.; Allikmec, L. (Tartu Univ., Tartu, USSR). Byull. Eksp. Biol. Med., 96(12), 49-50 (Russian) 1983. CODEN: BEBMAE. ISSN: 0365-9615. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In mice, 25 h after chronic treatment with fenibut [1078-21-3] (100 mg/kg, twice daily for 10 days) was discontinued, the no. of benzodiazepine and GABAA (bicucullin-sensitive) receptor sites was increased and 48 h after treatment discontinuation the no. of GABAB (bicucullin nonsensitive) sites was decreased. Enhanced binding to GABAA and GABAB receptor sites and decreased binding to benzodiazepine receptors was obsd. 24 h after discontinuation of chronic treatment with diazepam [439-14-5] (5 mg/kg, twice daily). Forty-eight h after diazepam chronic treatment was discontinued, the no. of benzodiazepine receptor sites was increased. Involvement of increased benzodiazepine receptor sensitivity in the mechanism of therapeutic activity of fenibut is suggested. .

Pharmacological correction of traumatic brain edema

Pharmacological correction of traumatic brain edema. Novikov, V. E.; Yasnetsov, V. S. (Smolensk.Some commonly used reagents like 56-12-2 and 127-17-3 are used in this experiment. Med. Inst., Smolensk, USSR). Farmakol. Toksikol. (Moscow), 47(1), 34-7 (Russian) 1984. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Diazepam [439-14-5], phenazepam [51753-57-2], and phenibut [1078-21-3] markedly inhibited the development of exptl. traumatic edema in the brains of rats and counteracted trauma-induced increases in the lactate [50-21-5]/pyruvate [127-17-3] index. Pantogam [17097-76-6], nicotinoyl-GABA [34562-97-5], and piracetam [7491-74-9], however, were ineffective. The antiedematous activity of the 1st 3 drugs appears to involve the activation of brain GABAergic systems, as well as the participation of adreno- and cholinoreactive structures involved in brain metab. .