144701-48-4 (Telmisartan)

1. Introduction of Telmisartan (CAS NO.: 144701-48-4)

Telmisartan (CAS NO.: 144701-48-4) is a kind of white crystalline powder with no odour and taste and it is soluble in chloroform, sparingly soluble in methylene dichloride, slightly soluble in methanol, very slightly soluble in ethanol, ethyl acetate & acetone and practically insoluble in water.

Telmisartan is in a gruop of drugs named as angiotensin II receptor blockers, or ARBs for short. This product is indicated in the treatment of hypertension (high blood pressure), which is effective in lowdering both systolic and diastolic blood pressure and could then cause blood vessels to relax. Beside, Telmisartan could also be applied to reduce the risk of stroke, heart attack or even death on people. And it could have effect on those patients who have no ablity of taking ACE inhibitors.

2. Basic Information of Telmisartan (CAS NO.: 144701-48-4)

1). General Knowledge of Telmisartan
 

Telmisartan, with its CAS registry number 144701-48-4, has its systematic name of 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid. With its chemical formula of C₃₃H₃₀N₄O₂ and molecular weight of 514.63, it belongs to the applicable category which includes Cardiovascular agents.

2). Specification of Telmisartan (CAS NO.: 144701-48-4)

Telmisartan (CAS NO.: 144701-48-4) has the following specification details: (1)Purity: ≥99% on the anhydrous basis; (2)Loss on drying: ≤0.5%; (3)Appearance of solution: clear, colorless; (4)PH: 5.0-6.0; (5)Related impurities: The peak area of total impurities ≤1%; (6)Heavy metal: ≤10ppm; (7)Applicable category: Hypotensive.

3). Properties of Telmisartan (CAS NO.: 144701-48-4)

The other characteristics of Telmisartan can be summarized as: (1)ACD/LogP: 7.73; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 5.65; (4)ACD/LogD (pH 7.4): 4.76; (5)ACD/BCF (pH 5.5): 3685.42; (6)ACD/BCF (pH 7.4): 473.14; (7)ACD/KOC (pH 5.5): 3186.89; (8)ACD/KOC (pH 7.4): 409.13; (9)#H bond acceptors: 6; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 61.94; (13)Index of Refraction: 1.667; (14)Molar Refractivity: 154.51 cm³; (15)Molar Volume: 414.9 cm³; (16)Polarizability: 61.25×10^-24cm³; (17)Surface Tension: 48.7 dyne/cm ; (18)Density: 1.24 g/cm³; (19)Flash Point: 420.6 °C; (20)Enthalpy of Vaporization: 117.87 kJ/mol; (21)Boiling Point: 771.9 °C at 760 mmHg; (22)Vapour Pressure: 4.58E-25 mmHg at 25°C.

4). Manufacture of Telmisartan (CAS NO.: 144701-48-4)

Telmisartan (CAS NO.: 144701-48-4) could be produced through the following two ways:

(1). This method is usually applied in the industrial production: Prepare the raw material of 3-methyl-4-Amino-benzoic acid, and then go through a list of process of esterification, acylation, nitration, deoxidation, cyclization, hydrolyzation to obtain the compound 2-propyl-4-methyl-6-carboxy benzimidazole. Next, the compound go through the condensation process with N-methyl-o-phenylenediamine in the action of polyphosphoric acid to give the resultant, which could then react with 2-cyano-4- (bromomethyl) biphenyl and then hydrolyze to produce the final product Telmisartan.

(2). Telmisartan (CAS NO.: 144701-48-4) could also be synthesized through the following reaction routes:
 

5). Safety Information of Telmisartan (CAS NO.: 144701-48-4)

When you are dealing with Telmisartan (CAS NO.: 144701-48-4), you should be careful and then take some measures to protect youreself from danger. For being irritating to eyes, respiratory system and skin, it may cause inflammation to the skin or other mucous membranes. Therefore, you should wear suitable protective clothing and avoid contact with skin and eyes while using. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and do not breathe dust while dealing with this chemical.

6). Descriptors of Structure

(1). SMILES:O=C(O)c1ccccc1c2ccc(cc2)Cn3c4cc(cc(c4nc3CCC)C)c5nc6ccccc6n5C
(2). InChI:InChI=1/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
(3). InChIKey:RMMXLENWKUUMAY-UHFFFAOYAZ

3. Package & Storage of Telmisartan (CAS NO.: 144701-48-4)

(1). Packing information of Telmisartan (CAS NO.: 144701-48-4): 10 kg/drum.
(2). Telmisartan can also be packed according to the customer requirements and packaging specifications.