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Detail of "145040-37-5"

  • CAS Number:
  • 145040-37-5
  • Name:

  • Candesartan cilexetil

  • Molecular Structure:
  • Formula:
  • C33H34N6O6
  • Molecular Weight:
  • 610.67
  • Synonyms:
  • 1H-Benzimidazolium, 7-carboxy-1-(2-((cyclohexylcarbonyl)oxy)ethyl)-2-ethoxy-1-(2-(1H-tetrazol-5-yl)(1,1-biphenyl)-4-yl)-, hydroxide, inner salt, (+-)-;TCV-116;Atacand;Atacand (TN);1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzoimidazole-4-carboxylate;TCV 116;Candesartancilexetil;
  • Density:
  • 1.37 g/cm3
  • Boiling Point:
  • 843.3 ºC at 760 mmHg
  • Flash Point:
  • 463.8 ºC
  • Hazard Symbols:
  • HarmfulXn
  • Risk Codes:
  • 20/21/22-36/37/38
  • Safety:
  • 26-36 Details
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name:Candesartan cilexetil Another name:1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate CAS NO.:145040-37-5 Mol Structure: Mol Fm: C33H34N6O6 Mol Wt: 610.67 Char: white crystal powder A

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Reference

Application of first derivative UV-spectrophotometry and ratio derivative spectrophotometry for the simultaneous determination of candesartan cilexetil and hydrochlorothiazide
Application of first derivative UV-spectrophotometry and ratio derivative spectrophotometry for the simultaneous determination of candesartan cilexetil and hydrochlorothiazide. Erk, N. (Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Tandogan-Ankara, Turk.). Pharmazie, 58(11), 796-800 (English) 2003 Govi-Verlag Pharmazeutischer Verlag GmbH. CODEN: PHARAT. 145040-37-5 and 58-93-5 are also occured in this study. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Two-component mixts. of candesartan cilexetil (CAN) and hydrochlorothiazide (HYD) were assayed by 1st deriv. and ratio deriv. spectrophotometry. The 1st method depends on zero-crossing and peak to base measurement. The 1st deriv. amplitudes at 270.1 and 255.5 nm were selected for the assay of (CAN) and (HYD), resp. The 2nd method depends on 1st deriv. of the ratio spectra by division of the absorption spectrum of the binary mixt. by a normalized spectrum of 1 of the components and then calcg. the 1st deriv. of the ratio spectrum. The 1st deriv. of the ratio amplitudes at 236, 250, 232, 267, and 280 nm were selected for the detn. of (CAN) and (HYD), resp. Calibration curves were established for 6.0-38.0 mg × ml-1 for (CAN) and 4.0-28.0 mg × ml-1 for (HYD) in binary mixts. Good linearity, precision, and selectivity were found, and the 2 methods were successfully applied to the pharmaceutical dosage form contg. the above-mentioned drug combination without any interference by the excipients. .
Four-week intravenous toxicity study of M-I (CV-11974), an active and main metabolite of TCV-116, in beagle dogs
Four-week intravenous toxicity study of M-I (CV-11974), an active and main metabolite of TCV-116, in beagle dogs. Nishida, Nobuyuki; Ito, Takayasu; Chatani, Fumio; Sato, Shuzo; Mitani, Masayoshi (Pharmaceutical Development Division, Takeda Chemical Industries, Ltd., Japan). Yakuri to Chiryo, 25(1), 67-91 (Japanese) 1997 Raifu Saiensu Shuppan K.K. CODEN: YACHDS. ISSN: 0386-3603. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) M-I (CV-11974), an angiotensin II receptor antagonist and an active and main metabolite of TCV-116, was administered i.v. 145040-37-5 and 139481-59-7 which are cas registry numbers are also used here. to male and female beagle dogs at 0, 12, 60 and 300 mg/kg/day for 4 wk, and its toxicity was assessed. Biochem., histol., and clin. data are reported. The max. nontoxic dosage of M-I appeared to be 12 mg/kg/day. .
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