Detail of "148-18-5"

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CAS Number:
148-18-5
Name:
Sodium diethyldithiocarbamate
Molecular Structure:
Formula:
C₅H₁₀NNaS₂
Molecular Weight:
171.27
Deleted CAS:
143189-63-3|149099-81-0|19622-06-1
Synonyms:
Sodium N,N-diethyldithiocarbamate;Carbamic acid, diethyldithio-, sodium salt;DEDC;Soxinol ESL;Diethyldithiocarbamic acid, sodium;Usaf ek-2596;DEDK;Ditiocarb sodium;Diethyldithiocarbamic acid, sodium salt;Thiocarb;GS 694A;NCI-C02835;DTC;DDC;
EINECS:
205-710-6
Density:
1.086 g/cm³
Melting Point:
95 °C
Boiling Point:
176.4 °C at 760 mmHg
Flash Point:
60.5 °C
Solubility:
water: >=10 g/100 mL at 14 °C
Appearance:
Odorless white or slightly brown or slightly pink crystals

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Impairment of retention of avoidance responses in rats by posttraining diethyldithiocarbamate: Impairment of retention of avoidance responses in rats by posttraining diethyldithiocarbamate. Spanis, C. W.; Haycock, J. W.; Handwerker, M. J.; Rose, R. P.; McGaugh, J. L. (Sch. Biol. Sci., Univ. California, Irvine, Calif., USA). Psychopharmacology (Berlin), 53(2), 213-15 (English) 1977. CODEN: PSCHDL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Na diethyldithiocarbamate (DDC) [148-18-5] (680 mg/kg), administered immediately after training, impaired rats' retention, 6 days later, of a one-way active avoidance task and a discriminated active avoidance task. In the discrimination task a lower dose (240 mg/kg) also impaired retention. Delayed posttraining injections did not affect retention in either task. Thus, DDC can have similar effects on retention of tasks requiring quite different behavioral responses.

Inhibitors of colon carcinogenesis: Inhibitors of colon carcinogenesis. Wattenberg, Lee W.; Lam, Luke K. T.; Fladmoe, Alan V.; Borchert, Peter (Dep. Lab. Med. Pathol., Univ. Minnesota, Minneapolis, Minn., USA). Cancer (Philadelphia), 40(5, Suppl.), 2432-5 (English) 1977. CODEN: CANCAR. ISSN: 0008-543X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 Disulfiram [97-77-8] and Na diethyldithiocarbamate [148-18-5], when added to the diet, inhibit 1,2-dimethylhydrazine (DMH) [540-73-8]-induced neoplasia of the large bowel in mice. Maneb [12427-38-2] and bisethylxanthogen [502-55-6], 2 pesticides with structural similarities to disulfiram, produce comparable inhibition of DMH. In other work, disulfiram inhibited the carcinogenic effect of azoxymethane (AOM) [25843-45-2] on the large bowel. Under comparable conditions the inhibition of AOM was considerably less than that obtained with DMH as the carcinogen. The data suggest that disulfiram inhibits DMH metab. at more than 1 oxidative step.