Detail of "15570-12-4"

CAS Number:
15570-12-4
Name:
3-Methoxybenzenethiol
Molecular Structure:
Formula:
C₇H₈OS
Molecular Weight:
140.20
Synonyms:
Benzenethiol,m-methoxy- (6CI,7CI,8CI);(m-Methoxyphenyl)thiol;3-Mercaptoanisole;3-Methoxythiophenol;m-Methoxybenzenethiol;m-Methoxythiophenol;
EINECS:
239-617-7
Density:
1.112 g/cm³
Boiling Point:
223.5 °C at 760 mmHg
Flash Point:
96.1 °C
Appearance:
clear colorless to light yellow liquid
Hazard Symbols:
Xi,Xn
Risk Codes:
20/21/22-36/37/38-22
Safety:
26-36/37-37/39 Details
Transport Information:
UN 2810 6.1/PG 3

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Antiestrogenic and antiandrogenic benzothiophenes: Antiestrogenic and antiandrogenic benzothiophenes. Jones, Charles D. (Lilly, Eli, and Co. , USA). U.S. US 4418068 A 29 Nov 1983, 23 pp. Cont.-in-part of U.S. Ser. No. 246,335, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-445; C07D409-12. NCL: 424267000. APPLICATION: US 81-331042 16 Dec 1981. PRIORITY: US 81-246335 3 Apr 1981. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 63 Antiandrogenic and antiestrogenic [(piperidinoethoxy)benzoyl]benzothiophenes I [R,R1 = H, R2CO; R2 = H, cycloalkyl, (un)substituted alkyl, Ph] were prepd. Thus, 2-(4-hydroxyphenyl)benzo[b]thiophene-6-ol was esterified with MeSO2Cl and the diester subjected to Friedel-Crafts acylation with 4-(2-piperidinoethoxy)benzoyl chloride to give I (R = R1 = MeSO2). This was sapond. to give I (R = R1 = H) (II). Immature female rats administered 0.03 mg estradiol propionate (III) s.c. together with 3 mg II s. 84541-31-1 and 15570-12-4 which are cas registry numbers of chemicals are mentioned.c. daily for 4 d had av. uterus wt. of 21.3 mg. Those given III alone had av. uterus wt. of 65.9 mg. I also were effective as antiandrogens and as mammary tumor inhibitors. .