Reference

Adriamycin analogs

Adriamycin analogs. 2. Synthesis of 13-deoxyanthracyclines. Smith, Thomas H.; Fujiwara, Allan N.; Henry, David W. (Bio-Org. Chem. Dep., Stanford Res. Inst. Int., Menlo Park, Calif., USA). J. Med. Chem., 21(3), 280-3 (English) 1978. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 26, 33 Reaction of daunorubicin-HCl [23541-50-6] and adriamycin-HCl [25316-40-9] with p-toluenesulfonylhydrazide [1576-35-8] followed by redn. of the tosylhydrazones with NaCNBH3 gave 13-deoxydaunorubicin-HCl (I) [65360-28-3] and 13-deoxyadriamycin-HCl (II) [65360-29-4], resp. Condensation of e-rhodomycinone [21288-60-8] with 1-chloro-3-N-(trifluoroacetyl)-4-O-(p-nitrobenzoyl)daunosamine [63700-25-4] followed by deprotection gave III [65360-32-9]. I and II were comparable in activity to the parent compds. against P388 leukemia in mice, while III was less active than I. The intermediate tosylhydrazones in the prepn. of I and II had high activity against in vivo P388 leukemia at high doses. Structure-activity relations are discussed.

Purification of styrene polymers

Purification of styrene polymers. Camerman, P. (Labofina S. A., Belg.). Belg. BE 859798 15 Feb 1978, 11 pp. (French). (Belgium). CODEN: BEXXAL. CLASS: IC: C08F. PRIORITY: GB 76-43757 21 Oct 1976. DOCUMENT TYPE: Patent CA Section: 36 (Plastics Manufacture and Processing) The content of residual monomers in styrene polymers, such as an acrylonitrile-styrene copolymer (I) [9003-54-7], was reduced by heating the polymer with p-MeC6H4SO2NHNH2 (II) [1576-35-8], PhSO2NHNH2 [80-17-1], [p-(H2NNHSO2)C6H4]2O [80-51-3], or a similar arom. sulfonyl hydrazide. Thus, a I contg. 0.14% styrene and 0.08% acrylonitrile was mixed with 0.4% II and 0.07% Zn stearate and extruded at 220° to give I contg. 0.05% styrene and 0.02% acrylonitrile, compared with 0.12 and 0.07%, resp., without the addn. of II.