Reference

Cometabolism of DDT analogs by a Pseudomonas sp

Cometabolism of DDT analogs by a Pseudomonas sp. Francis, A. J.; Spanggord, R. J.; Ouchi, G. I.; Bohonos, N. (Stanford Res. Inst., Menlo Park, Calif., USA). Appl. Environ. Microbiol., 35(2), 364-7 (English) 1978. CODEN: AEMIDF. ISSN: 0099-2240. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemicals) A Pseudomonas sp. capable of growth on several nonchlorinated and mono-p-chloro-substituted analogs of DDT as a sole carbon source degraded bis(p-chlorophenyl)methane [101-76-8] and 1,1-bis(p-chlorophenyl)ethane [3547-04-4] only in the presence of diphenylethane. The products p-chlorophenylacetic acid [1878-66-6] and 2-(p-chlorophenyl)propionic acid [938-95-4] were not further metabolized by the bacterium. Other chlorinated analogs of DDT were found to be recalcitrant to cometabolic degrdn. with diphenylethane.

Taurine conjugates as metabolites of arylacetic acids in the ferret

Taurine conjugates as metabolites of arylacetic acids in the ferret. Idle, Jeffrey R.; Millburn, Peter; Williams, R. Tecwyn (Med. Sch., St. Mary's Hosp., London, Engl.). Xenobiotica, 8(4), 253-64 (English) 1978. 103-82-2 is just another one chemical used in this study. CODEN: XENOBH. ISSN: 0049-8254. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Phenylacetic acid (I) [103-82-2], 4-chlorophenylacetic acid (II) [1878-66-6], 4-nitrophenylacetic acid (III) [104-03-0], a-methylphenylacetic acid (IV) [492-37-5], 1-naphthylacetic acid (V) [86-87-3], 2-naphthylacetic acid (VI) [581-96-4], and indol-3-ylacetic acid (VII) [87-51-4] administered to ferrets were excreted in the urine as taurine and glycine conjugates. Diphenylacetic acid [117-34-0] did not form an amino acid conjugate and was excreted as a glucuronide. The taurine conjugate was the major metabolite of III, IV, V, VI, and VII whereas the glycine conjugate was the major metabolite of I and II. Taurine conjugation did not occur with benzoic acid [65-85-0] and 4-nitrobenzoic acid [62-23-7], which were excreted as glycine and glucuronic acid conjugates. The role of taurine as an alternative to glycine in the metabolic conjugation of arylacetic acids is discussed. .