Reference

Lubricant for pressure forming of oil tanks

Lubricant for pressure forming of oil tanks. (Matsushita Electric Industrial Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59020392 A2 2 Feb 1984 Showa, 3 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C10M001-08; B21D022-20. APPLICATION: JP 82-130810 27 Jul 1982. DOCUMENT TYPE: Patent CA Section: 51 (Fossil Fuels, Derivatives, and Related Products) The title lubricant contains chlorinated paraffin wax ￡1, glycerol ester ￡0.5, oleyl alc. [143-28-2] ￡0.5, sorbitan monooleate [1338-43-8] ￡0.5, fatty acid ￡1.5, org. sulfides ￡0.5, tricresyl phosphate [1330-78-5] ￡1, silicone oil ￡0.5, 2,4-dimethyl-6-tert-butylphenol [1879-09-0] ￡0.5, N,N'-di-sec-butyl-p-phenylenediamine [101-96-2] ￡1.5, Pb naphthenate ￡0.5, and hydrocarbon oil 92-100 parts. The lubricant has antirusting properties.

Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation

Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation. Malkinson, Alvin M.; Beer, Deborah S. (Sch. Pharm., Univ. Colorado, Boulder, CO 80309, USA). JNCI, J. Natl. Cancer Inst., 73(4), 925-33 (English) 1984. CODEN: JJIND8. ISSN: 0198-0157. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Section cross-reference(s): 1 The food additive BHT [128-37-0] can modulate the formation of lung adenomas in mice treated with the carcinogen urethane [51-79-6]. An i.p. injection of BHT administered 6 h before a single urethane injection decreased the no. of tumors formed, whereas 6 weekly BHT injections following a single urethane dose increased tumor multiplicity. Biotransformation of BHT was apparently required for both prophylaxis and enhancement. Pretreatment of mice with cedrene, which perturbs drug metab., prevented both of these BHT activities. Analogs of BHT with different substitutions at position 6 of the phenol ring also affected tumor formation. 2-tert-Butyl-4-methylphenol [2409-55-4] inhibited, no enhanced, adenoma formation. 2-tert-Butyl-4,6-dimethylphenol (BDMP) [1879-09-0] increased tumor no. in A/J but not in the BALB/cByJ mouse strain; its prophylactic activity could not be measured since urethane injection following BDMP treatment was lethal. Thus, the presence of an alkyl group at this site on the phenol ring was not required for prophylaxis but was necessary for tumor enhancement. These results were consistent with the possibility that different BHT metabolites were responsible for each effect. Adenoma formation was enhanced by BHT in 4 strains of mice with a U+ phenotype (susceptible to urethane-induced lung adenomas). BHT had no such effect, however, in the U+ strain 129/J. A U+B- phenotype (urethane inducible but unresponsive to BHT enhancement) also was found among the recombinant inbred lines originally derived from a cross between U+B+ BALB/cByJ and U-/B- C57BL/6ByJ progenitor strains. This finding showed that the genes detg. sensitivity to urethane and to BHT had recombined independently of each other. An inability to metabolize BHT was probably not involved in the B- phenotype, since BHT caused reversible lung damage in the 2 U+B- recombinant inbred lines and strain 129, and biotransformation was required for this effect. These U+B- mice thus can be used to characterize the lung toxic effects of BHT in the absence of its tumor-enhancing activity and will serve as valuable controls in studies on mechanisms of tumor enhancement.