Detail of "22161-81-5"

CAS Number:
22161-81-5
Name:
Benzeneacetic acid,3-benzoyl-a-methyl-, (aS)-
Superlist Name:
(S)-(+)-Ketoprofen
Molecular Structure:
Formula:
C₁₆H₁₄O₃
Molecular Weight:
254.28
Synonyms:
Benzeneaceticacid, 3-benzoyl-a-methyl-,(S)-;Hydratropic acid, m-benzoyl-, (+)- (8CI);(+)-(S)-m-Benzoylhydratropicacid;(+)-2-(3-Benzoylphenyl)propionic acid;(+)-3-Benzoyl-a-methylbenzeneacetic acid;(+)-3-Benzoylhydratropic acid;(+)-Ketoprofen;(2S)-2-(3-Benzoylphenyl)propionic acid;(S)-(+)-2-(3-Benzoylphenyl)propionicacid;(S)-2-(3-Benzoylphenyl)propionic acid;(S)-Ketoprofen;Dexketoprofen;
Density:
1.198 g/cm³
Melting Point:
75-78 °C(lit.)
Boiling Point:
431.3 °C at 760 mmHg
Flash Point:
228.8 °C
Solubility:
practically insoluble in water ,freely soluble in acetone, in ethanol(96 percent) and in methylene chloride
Appearance:
white or almost white, crystalline powder.
Hazard Symbols:
Xn, T
Risk Codes:
22-36/37/38-50/53
Safety:
26-60-61 Details
Transport Information:
UN 2811 6.1/PG 3

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

All Suppliers

Supplier Location
Supplier Location
- China (Mainland)(18)
- Paraguay(1)
- United States(1)
Business Type
Business Type
- Lab/Research institutions(2)
- Manufacturers(3)
- Trading Company(12)
Certificates
Certificates
- ISO(1)
- Production License(1)

Please post your buying leads>>

Display：

Manufacturer
Enterprise Authentication
Suppiers of more reward points first
New supplier

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Reference

Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs: Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. IV. Ketoprofen disposition. Abas, A.; Meffin, P. J. (Dep. Clin. Pharmacol., Flinders Univ. South Australia, Adelaide 5042, Australia). J. Pharmacol.Several reagents with their cas registry numbers 22161-86-0 and 56105-81-8 are used here. Exp. Ther., 240(2), 637-41 (English) 1987. CODEN: JPETAB. ISSN: 0022-3565. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The disposition of ketoprofen enantiomers was studied in rabbits with normal renal function or with renal dysfunction. In control animals a mean of 0.06 of R-ketoprofen [56105-81-8] was inverted to its S-enantiomer [22161-81-5]. The mean distribution vols. for R- and S-ketoprofen were 114 and 294 mL/kg, resp. The mean clearance of the R-enantiomer from plasma was 292 mL/kg/h compared to 36 mL/kg/h for the S-enantiomer. This high degree of enantioselectivity was not due to inversion, renal clearance or clearance by glucuronidation, but was the result of an unknown clearance process(es). Comparing the mean parameters of racemic ketoprofen [22161-86-0] disposition in renal dysfunction with those in the same animals during the control study, the mean fraction of the R-dose inverted increased by 290%, but this effect was not due to decreased clearance of R-ketoprofen renally or by glucuronidation. The distribution vols. of R- and S-ketoprofen were increased by 200 and 183% by renal dysfunction, consistent with an implied decrease in plasma protein binding. The clearances bound plus unbound R- and S-ketoprofen from plasma remained unaltered by renal dysfunction. .

Determination of the enantiomers of ketoprofen in blood plasma by ion-pair extraction and high-performance liquid chromatography of leucinamide derivatives: Determination of the enantiomers of ketoprofen in blood plasma by ion-pair extraction and high-performance liquid chromatography of leucinamide derivatives. Bjoerkman, Sven (Hosp. Pharm., Malmoe Gen. Hosp., Malmoe S-214 01, Swed.). J. Chromatogr., 414(2), 465-71 (English) 1987. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A previously described, facile HPLC method for the detn. of the enantiomers of indoprofen was revised for the detn. of the enantiomers of ketoprofen in the blood plasma of humans. Ketoprofen enantiomers were extd. 22161-81-5 and 56105-81-8 which are cas registry numbers are also used here. from acidified plasma followed by conversion to a mixed anhydride with Et chloroformate. The mixed anhydride was allowed to react with L-lucinamide and the enantiomers of the lucinamide derivs. were sepd. and quantitated by reversed-phase HPLC. The internal std. was 2-(4-benzoylphenyl)butyric acid. A LiChroCart RP-18 7-mm column was used in conjunction with a Hibar precolumn filled with Perisorb, the mobile phase was MeCN-10 mM phosphate buffer, pH 6.5 () and the detection wavelength was 260 nm. The std. curves were linear for 0.25-2.0 mg/mL and 1-16 mg/mL, resp. The method was satisfactory for pharmacokinetic studies. .

Detail of "22161-81-5"

Benzeneacetic acid,3-benzoyl-a-methyl-, (aS)-

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

CAS No.22161-81-5 (S)-(+)-Ketoprofen

Reference