CAS No.2622-26-6,PROPERICYAZINE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	2622-26-6
Name:	PROPERICYAZINE
Article Data:	4

Formula:	C21H23 N3 O S
Molecular Weight:	365.499
Synonyms:	Phenothiazine-2-carbonitrile,10-[3-(4-hydroxypiperidino)propyl]- (6CI,7CI,8CI); 10-[3-(4-Hydroxypiperidino)propyl]phenothiazine-2-carbonitrile;2-Cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine;2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine; Aolept; Bayer 1409; FI6145; Nelactil; Nemactil; Neulactil; Neuleptil; Periciazine; Periciazinum;Pericyazine; Properciazine; Propericiazine; Propericyazine; RP 8909; SKF 20716
Density:	1.32g/cm³
Melting Point:	116-117°
Boiling Point:	593.4°Cat760mmHg
Flash Point:	312.7°C
Solubility:	38.01mg/L(37 oC)
Hazard Symbols:
Risk Codes:	22-36/37/38-20/21/22
Safety:	Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN⁻, NO_x, and SO_x. See also NITRILES.
PSA:	75.80000
LogP:	4.01068

Synthetic route

: 5382-16-1
4-HYDROXYPIPERIDINE

: 38642-74-9
10H-phenothiazine-2-carbonitrile

: 109-70-6
1,3-chlorobromopropane

: 2622-26-6
periciazine

Conditions

Conditions	Yield
Stage #1: 10H-phenothiazine-2-carbonitrile; 1.3-chlorobromopropane With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 7h; Stage #2: 4-HYDROXYPIPERIDINE With triethylamine In N,N-dimethyl-formamide at 0 - 60℃; for 42h;	40%

...Expand

: 2622-26-6
periciazine

: 96265-39-3
10-(3-(4-oxopiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile

Conditions

Conditions	Yield
With dmap; 2-azatricyclo[3.3.1.13,7]dec-2-yloxidanyl; copper(l) chloride In acetonitrile at 20℃; for 1h; chemoselective reaction;	97%

: 13494-98-9
yttrium(III) nitrate

: 2622-26-6
periciazine

: Y(3+)*2C21H23N3OS*3NO3(1-) = [Y(C21H23N3OS)2(NO3)2](NO3)

Conditions

Conditions	Yield
In ethanol 15 min; pptn. washing (EtOH), drying (vac.); elem. anal.;	74%

: uranyl(VI) acetate dihydrate

: 2622-26-6
periciazine

: UO2(CH3CO2)2(C6H4SN((CH2)3NC5H9OH)C6H3CN)(H2O)2

Conditions

Conditions	Yield
In water soln. refluxed for 6 h; cooling under ice-cold water for 4 d; ppt. filtered and dried in vac.; elem. anal.;	50%

: zirconium(IV) nitrate

: 2622-26-6
periciazine

: Zr(NO3)4 (propericiazine)

Conditions

Conditions	Yield
In sulfuric acid; water aq. H2SO4; stirring (soln. of Zr(NO3)4 in water), addn. (soln. of ligand in water, sulphuric acid), pptn., set aside (2 h); sepn. (filtration), washing (water, EtOH), drying (vac., over fused CaCl2); elem. anal.;

: rhodium(III) chloride trihydrate

: 2622-26-6
periciazine

: rhodium (II,III) (propericiazine)2 Cl8

Conditions

Conditions	Yield
In ethanol addn. of ethanolic soln. of PPC to a constantly stirred ethanolic soln. of RhCl3*3H2O at room temp., pptn.; filtration, washing with ethanol and ether, drying in vac. over fused CaCl2, elem. anal.;

: ruthenium(III) chloride trihydrate

: 2622-26-6
periciazine

: Ru3(C6H4SN(C3H6N(C5H9OH))C6H3(CN))2Cl8

Conditions

Conditions	Yield
In ethanol addn. of ethanolic N-alkylphenothiazine soln. to ethanolic RuCl3*3H2O soln., stirring slowly; filtration; washing (ethanol, ether, several times); drying (anhydrous CaCl2, desiccator); elem. anal.;

: 10213-10-2
sodium tungstate (VI) dihydrate

: 2622-26-6
periciazine

: W2O4(C6H4SN((CH2)3NC5H9OH)C6H3CN)2(H2O)2

Conditions

Conditions	Yield
With HCl In water a soln. of Na2WO4*2H2O in distd. H2O was added with stirring to a soln.of PPC in distd. H2O containing few drops of 2 M HCl; the suspn. was set aside for 3 h, filtered, washed (H2O, EtOH), dried in vac. over fused CaCl2; elem. anal.;

: hexaammonium heptamolybdate tetrahydrate

: 2622-26-6
periciazine

: Mo2O4(C6H4SN(CH2)3NC5H9OHC6H3CN)2(H2O)2

Conditions

Conditions	Yield
In hydrogenchloride (NH4)6Mo7O24*4H2O in 2 M HCl was added to soln. of ligand in water with vigorous stirring, suspn. set aside for 2 h; suspn. filtered, washed with water, ethanol and dried in vacuo over fused CaCl2; elem. anal.;	67-79

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Chemistry

Empirical Formula: C₂₁H₂₃N₃OS
Molecular Weight: 365.4918 g/mol
EINECS: 220-071-3
Index of Refraction: 1.694
Density: 1.32 g/cm³
Flash Point: 312.7 °C
Storage tempreture: 2-8 °C
Enthalpy of Vaporization: 93.04 kJ/mol
Boiling Point: 593.4 °C at 760 mmHg
Vapour Pressure: 6.29E-15 mmHg at 25 °C
Structure of Propericiazine (CAS NO.2622-26-6):

IUPAC Name of Propericiazine (CAS NO.2622-26-6): 10-[3-(4-Hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)	Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
mouse	LD50	intraperitoneal	115mg/kg (115mg/kg)	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
mouse	LD50	intravenous	27700ug/kg (27.7mg/kg)	Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967.
mouse	LD50	oral	530mg/kg (530mg/kg)	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
mouse	LD50	subcutaneous	375mg/kg (375mg/kg)	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 157, Pg. 1242, 1963.
rat	LD50	intraperitoneal	85mg/kg (85mg/kg)	"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.
rat	LD50	intravenous	35mg/kg (35mg/kg)	"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.
rat	LD50	oral	395mg/kg (395mg/kg)	Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat	LD50	subcutaneous	1200mg/kg (1200mg/kg)	"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 43, 1972.

Consensus Reports

Cyanide and its compounds are on the Community Right-To-Know List.

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN⁻, NO_x, and SO_x. See also NITRILES.
Hazard Codes of Propericiazine (CAS NO.2622-26-6): Harmful Xn
Risk Statements: 22-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

Specification

Propericiazine ,its cas register number is 2622-26-6. It also can be called Neuleptil ; Aolept ; periciazine ; and 2-Cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine .