Reference

Derivatives of 1-phenyl-2-piperidinopropanol and medicines containing it

Derivatives of 1-phenyl-2-piperidinopropanol and medicines containing it. Wick, Alexander; Frost, Jonathan; Gaudilliere, Bernard; Bertin, Jean; Dupont, Regis; Rousseau, Jean (Synthelabo S. A. , Fr.). Fr. Demande FR 2534580 A1 20 Apr 1984, 53 pp. (French). (France). CODEN: FRXXBL. CLASS: IC: C07D211-14; A61K031-445. APPLICATION: FR 82-17187 13 Oct 1982. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) 1-Piperidineethanols I (R = H, halo, CF3, alkyl, OH, alkoxy, PhCH2O, alkanoyloxy, PhCO2, CH2OH, CONH2, carbalkoxy; R1 = H, halo, alkyl, OH, alkoxy; R2 = H, alkyl; R3 = Me, H; R4 = H, halo, alkyl, alkoxy, and R5 = R6 = H, or R4 = R5 = R6 = OMe) were prepd., and they are useful as anti-ischemic agents (no data). 4-(4-Methylbenzyl)piperidine was N-alkylated by 4-HOC6H4COCHBrMe, and the N-phenylpiperidine deriv. 92821-96-0 which is the cas registry number is also used here. obtained was contacted with H over Pd to give I (R = 4-OH, R1 = R2 = R5 = R6 = H, R3 = R4 = Me). .

Biotransformation of heptacaine hydrochloride in vitro

Biotransformation of heptacaine hydrochloride in vitro. Helia, O.; Cizmarik, J. (Pharm. Fac., Komensky-Univ., Bratislava CS-832 32, Czech.). Pharmazie, 39(3), 189 (German) 1984. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Heptacaine (I) [55792-21-7] was metabolized by rat microsomal mono-oxygenase system of liver or kidney to heptacaine-N-oxide [77463-82-2], 2-heptyloxyaniline [55792-44-4], piperidinoethanol (II) [3040-44-6], and 2 unidentified metabolites which possibly could be hydroxylated products of I, or II.