Reference

Effects of chromosome repatterning in Vicia faba L

Effects of chromosome repatterning in Vicia faba L. II. Aberration clustering after treatment with chemical mutagens and x-rays as affected by segment transposition. Rieger, R.; Michaelis, A.; Schubert, I.; Kaina, B. (Zentralinst. Genet. Kulturpflanzenforsch., DAW, Gatersleben, E. Ger.). Biol. Zentralbl., 96(2), 161-82 (English) 1977. CODEN: BIZNAT. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Five structurally reconstructed karyotypes of V. faba were used to study the patterns of intrachromosomal distribution of chromatid aberrations induced by ethanol [64-17-5], cytostasan [3543-75-7], maleic hydrazide [123-33-1], mitomycin C [50-07-7], and x-rays and to look for influences of karyotype reconstruction on the patterns of aberration distribution. All mutagens used resulted in patterns of preferential aberration distribution; in most cases, segments which were found to represent potential aberration hot spots contained heterochromatin. The pattern of aberration distribution was, in part at least, mutagen specific and may be influenced by differences in the immediate chromosomal neighborhood of a potential hot spot, by structural reconstruction of the relevant chromosome, and by the residual karyotype; not any karyotype reconstruction may be expected to result in changes of mutagen-specific hot spot localization and expression. The most pronounced clustering in certain chromosomes regions of induced chromatid aberrations occurred after treatment with chem. mutagens; x-rays resulted in hot spots of significantly lower expressivity.

Quantitative evaluation of the effectiveness of inducing sister chromatid exchanges and chromosomal aberrations under the influence of chemical mutagens

Quantitative evaluation of the effectiveness of inducing sister chromatid exchanges and chromosomal aberrations under the influence of chemical mutagens. Shcheglova, E. G.; Chebotarev, A. N. (Kazan. Med. Inst., Kazan, USSR). Tsitol. Genet., 18(4), 298-301 (Russian) 1984. CODEN: TGANAK. ISSN: 0564-3783. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 The frequency of induction of sister chromatid exchanges (SCE) by E 39 [436-40-8], Dimatif [14465-96-4], thiophosphamide [52-24-4], mitomycin C [50-07-7], and IMET 3393 [3543-75-7] in human lymphocytes treated with the mutagens for 1 h after 48-h culturing, increased linearly with the mutagen concn. The efficiency of the above mutagens in inducing chromosomal aberrations was 100-300-fold lower than the induction of SCE and the dependence on concn. was nonlinear.