Detail of > 80214-83-1
- CAS Number:
- 80214-83-1
- Name:
Roxithromycin
- Formula:
- C41H76N2O15
- Molecular Structure:
- Synonyms:
- Roxithromycin，Stearyl Glycyrrhetinate;Roxithromycin EP;RU 965;Rulide (TN);Roxithromycinum [Latin];RU 28965;9-(O-((2-Methoxyethoxy)methyl)oxime)erythromycin;Roxithromycin (JP14/USAN);Roxithromycine [French];(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one;Roxitromicina [Spanish];Rulide;Prestwick_1046;Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime), (9E)-;
- Molecular Weight:
- 837.05
- Density:
- 1.25 g/cm3
- Melting Point:
- 111-118 °C
- Boiling Point:
- 864.7 °C at 760 mmHg
- Flash Point:
- 476.7 °C
- Appearance:
- white crystalline powder
- Hazard Symbols:
Xn- Risk Codes:
- 22
- Safety:
- 26Details
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Reference
- Roxithromycin bioassay procedures for human plasma, urine and milk specimens
- Roxithromycin bioassay procedures for human plasma, urine and milk specimens. Barry, A. L.; Packer, R. R. (Clin. Microbiol. Inst., Tualatin, OR 97062, USA). Eur. J. Clin. Microbiol., 5(5), 536-40 (English) 1986. CODEN: EJCMDM. ISSN: 0722-2211. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A Widal-type agglutination bioassay modified for measurement of roxithromycin (I) [80214-83-1] in human plasma, urine, milk and mouse plasma was developed. Bioassay plates were prepd. using Antibiotic Medium No. 11 (pH 8.0) and Sarcina lutea as test organism. Both urine and plasma assays consistently detected I concns. 31.0 mg/mL while in some human milk samples and mouse plasma concns. as low as 0.25 mg/mL were detected. The accuracy and precision of the I assay procedures are satisfactory for most clin. applications.
- HPLC analysis of roxithromycin and its related substances in its tablets
- HPLC analysis of roxithromycin and its related substances in its tablets. Dai, Hong; Hu, Changqin (Beijing Institute for Drug Control, Beijing 100035, Peop. Rep. China). 80214-83-1 are also occured in this study. Yaowu Fenxi Zazhi, 22(3), 185-188 (Chinese) 2002 Yaowu Fenxi Zazhi Bianji Weiyuanhui. CODEN: YFZADL. ISSN: 0254-1793. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Roxithromycin and its related substance in tablets were detd. by HPLC on ODS column (250 mm x 4.6 mm. 5 mm) with 0.067 mol L-1 ammonium dihydrogen phosphate soln. (adjusted pH to 6.5 by triethylamine) and acetonitrile (3:2) as mobile phase. The flow rate was 1 mL min-1 and the detective wavelength was 210 nm. The content of roxithromycin and its related substance were calcd. with the external std. method. The linear range of roxithromycin was 0.5 - 4.0 mg mL-1 with r = 1.0. The linear range of the related substance was 0.5 - 50 mg mL-1; the limit detection was about 0.01 mg and the LOQ was about 0.04 mg. The method was accurate, simple and quick and could be used to analyze roxithromycin. .
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