Reference

Metabolic hydroxylation of the aromatic rings of 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE) by the rat

Metabolic hydroxylation of the aromatic rings of 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE) by the rat.Some chemicals with cas registry numbers like 60805-34-7 and 42019-78-3 are also used. Sundstrom, Goran (Lab. Environ. Chem., Univ. Amsterdam, Amsterdam, Neth.). J. Agric. Food Chem., 25(1), 18-21 (English) 1977. CODEN: JAFCAU. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 25 Four phenolic metabolites of p,p'-DDE (I) [72-55-9] were identified in rat feces after dosing with I. The structures of the metabolites, II [60805-35-8], III [56913-14-5], IV [56913-13-4], and V [56958-04-4] were ascertained by spectral and chromatog. comparisons with synthetic material. Two of the metabolites show structures which suggest the initial formation of an arene oxide in the metabolic process. .

Benzoylphenoxyacetic acid derivatives

Benzoylphenoxyacetic acid derivatives. Hamazaki, Yasuhiko; Yamamoto, Toshiyuki; Seri, Kenji; Sakasai, Masao; Sato, Reiko; Ishiyama, Nobuo (Kaken Chemical Co., Ltd., Japan). Ger. Offen. 42019-78-3 which is the cas registry number of some chemical is mentioned. DE 2757459 29 Jun 1978, 24 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07C069-67. PRIORITY: JP 76-156256 27 Dec 1976. DOCUMENT TYPE: Patent CA Section: 25 (Noncondensed Aromatic Compounds) Section cross-reference(s): 24, 1 (Benzoylphenoxy)acetic acid derivs. I (R = H, halo, lower alkyl or alkoxy; R1 = H or lower alkyl), which showed anticholesteremic and hypolipemic activity (mice and rats), were prepd. by condensing 4-HOC6H4COC6H4R (as the Na salt) with alkyl bromocyclohexylacetates (I, R = H, were obtained by hydrolysis of the esters). RC6H4COC6H4OCHPhCO2Et-4 (R = H, 2-, 3- and 4-F, 2-, 3- and 4-Cl, 2-, 3- and 4-Me) were prepd. similarly, using PhCHBrCO2Et, and were shown to be much less effective anticholesteremics and hypolipemics than I. .