Reference

Isolation of some substances from Cardaria draba L

Isolation of some substances from Cardaria draba L. Desv.; degradation products of sulforaphane. Prochazka, Z.; Huynh Kim Thoa; Stransky, K.; Leifertova, I.; Musilek, A.; Scholz, G. (Ustav Org. Chem. Biochem., CSAV, Prague, Czech.). Cesk. Farm., 26(9), 395-9 (Czech) 1977. CODEN: CKFRAY. ISSN: 0009-0530. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Several constituents, sulforaphan [4478-93-7], a mixt. of paraffins, a mixt. of higher fatty alcs., b-sitosterol [83-46-5] and Scholz's normalization factor, were isolated from the fresh juice of Cardaria draba (L.) Desv., syn. Lepidium draba L. The 1st mentioned drug was isolated in a larger amt. by means of a modification of a previously described method, and the last one was obtained from this plant for the 1st time by the use of a modification of the method described by Scholz. The stability of sulforaphan in water and alc. was studied and the products of its reaction with these solvents prepd. and their structure detd. In contrast to sulforaphan, the products of its degrdn. are antibacterially ineffective.

Methods and compositions using sulforaphane to treat conditions associated with neovascularization

Methods and compositions using sulforaphane to treat conditions associated with neovascularization. Wong, Kin-Ping; Wong, Ming-Chung; Ren, Dai (Wackvom, Ltd., Virgin I. (Brit.)). PCT Int. Appl. WO 2004012677 A2 12 Feb 2004, 26 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K. APPLICATION: WO 2003-US24455 5 Aug 2003. PRIORITY: US 2002-PV401130 5 Aug 2002. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) The invention provides a method to inhibit neovascularization in tissue by delivering to the cell or tissue an effective amt. of sulforaphane, or a pharmaceutically acceptable salt, deriv., or prodrug thereof. The invention further provides a method for treating a disease assocd. with hyperproliferation of endothelial cells and/or neovascularization by administering to a subject an effective amt.In this experiment, several chemicals are used like 4478-93-7 and 155320-20-0 of sulforaphane, or a pharmaceutically acceptable salt, deriv., or prodrug thereof. Kits to treat patients are also provided. .