Reference

Spectrophotometric determination of some acidic drugs using phenazine dyes

Spectrophotometric determination of some acidic drugs using phenazine dyes. Beltagy, Youssef A. (Fac. Pharm., Univ. Alexandria, Alexandria, Egypt). Zentralbl. Pharm., Pharmakother. Laboratoriumsdiagn., 116(9), 925-33 (English) 1977. CODEN: ZPPLBF. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Spectrophotometric detn. of several acidic drugs, i.e., Na salicylate [54-21-7], salicylic acid [69-72-7], acetylsalicylic acid [50-78-2], Na lauryl sulfate [151-21-3], saccharin [81-07-2], flufenamic acid [530-78-9], and cephalothin Na [58-71-9] involved extg. the ion-pair assocn. complexes of the drug and safranine [477-73-6] or neutral red [553-24-2] in a buffer with CHCl3 and measuring the absorbance of CHCl3 ext. Buffers used for safranine and neutral red were of pH 7.4 and 2.2, resp. For saccharin, the CHCl3 ext. absorbance was measured at 510 nm, whereas for neutral red at 510 nm for salicylates and cephalothin Na, and at 530 nm for saccharin and Na lauryl sulfate. The results obtained using this method were comparable to those of the official method. Sensitivity of the dyes varied from one drug to another, and data obtained showed higher sensitivity for safranine than neutral red. Flufenamic acid could not be detd. using neutral red.

Dyes as inhibitors for the hydrogen peroxide decomposition

Dyes as inhibitors for the hydrogen peroxide decomposition. Banthia, Ajit K.; Biswas, Sankar; Palit, Santi R. (Dep. Phys. Chem., Indian Assoc. Cultiv. Sci., Jadavpur, India). J. Indian Chem. Soc., 54(12), 1202-3 (English) 1977. CODEN: JICSAH. ISSN: 0019-4522. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The rate of O evolution from H2O2 decompn. was inhibited by auramine (I) [2465-27-2], safranine [477-73-6], methylene blue [61-73-4], floxine [6441-77-6], fluorescein [2321-07-5], methylviolet [8004-87-3], and malachite green [569-64-2] in that order, resp. The mechanism by which dyes inhibit H2O2 decompn. is discussed. The relation between toxicity of the dyes and their inhibitory action on H2O2 decompn. is also discussed.