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Detail of "546-88-3"

  • CAS Number:
  • 546-88-3
  • Name:

  • Acetohydroxamic acid

  • Molecular Structure:
  • Formula:
  • C2H5NO2
  • Molecular Weight:
  • 75.07
  • Synonyms:
  • Acetohydroxamicacid (6CI,8CI);AHA;Acetic acid, oxime;Acetohydroximic acid;Acetylhydroxylamine;Hydroxylamine, N-acetyl-;Methylhydroxamic acid;N-Acetylhydroxylamine;N-Hydroxyacetamide;Acetomenadione;
  • EINECS:
  • 208-913-8
  • Density:
  • 1.155 g/cm3
  • Melting Point:
  • 88-90 °C(lit.)
  • Boiling Point:
  • 231.4 °C at 760 mmHg
  • Flash Point:
  • 127.6 °C
  • Appearance:
  • White crystalline solid
  • Hazard Symbols:
  • ToxicT
  • Risk Codes:
  • 61-40
  • Safety:
  • 53-45-36/37/39-22 Details
  • Transport Information:
  • UN 3263
  • particular:
  • particular
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546-88-3 Acetohydrocamlc acid USP31

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CAS No.546-88-3 Acetohydroxamic acid

Content 98.0~101.0% > 96.0% Loss on drying < 1.0% < 3.0% Residue on ignition < 0.1% < 0.2% Heay metals < 0.002% < 0.01% M.P. 88~92 C > 86 C

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CAS No.546-88-3 Acetohydroxamic acid

Nearly odourlessness, bitter taste. color deteriorated when meeting light; Easily absorbing moisture; insoluble in water, Absolute ethyl alcohol; The peroxide solution assumes adjusts the acid reaction (low-acid). As the rumen microorganism urine enzyme inhibitor in the feed i

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CAS No.546-88-3 Acetohydroxamic acid

Chemical Name: N-Hydroxyacetamide Catalog Number: C-00032 CAS Number: 546-88-3 Molecular Formula: C2H5NO2 Molecular Weight: 75.07 Purity: 98%

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Product name:Acetohydroxamic acid Category:Antinephrotithiasis agents

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CAS No.546-88-3 Acetohydroxamic acid

Molecular Formula C2H5NO2 Molecular Weight 75.07

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ACETOHYDROXAMIC ACID

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Reference

Coated particles of acetohydroxamic acid
Coated particles of acetohydroxamic acid. Foguet Ambros, Rafael; Fernandez Navarro, Carlos; Ortiz Hernandez, Jose A.; Sacristan Munoz, Aurelio (Ferrer Internacional S. A., Spain). Span. ES 513313 A1 1 Oct 1983, 14 pp. (Spanish). (Spain). CODEN: SPXXAD. CLASS: IC: A61K009-16; A61K031-185; A61K031-15. APPLICATION: ES 82-513313 24 May 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Coated particles of acetohydroxamic acid (I) [546-88-3] (50-500 mg), for pharmaceuticals are prepd. by dispersing I (moisture content ￡1%) in a polymeric binding agent of low water soly. (<0.5%, at 15-30°, and pH 5-8). Et cellulose [9004-57-3], poly(vinyl acetate phthalate) [53237-50-6] or its mixts. are preferred. The polymer is dissolved in an anhyd. solvent such as CHCl2 or CCl2:CHCl. This treatment is followed by atomization or coacervation (specific) and by the addn. 9003-20-7 and 54982-31-9 which are cas registry numbers of chemicals are mentioned. of a solvent in which the binder is insol., preferably Me2CO. This is followed by steam granulation after which particles sizes between 10 and 100m are obtained. I (50 g) were dissolved in 250 mL CCl2:CHCl soln. contg. 25 g Et cellulose. The suspension was homogenized and atomized using air at 150° at the entrance time and 90° at the exit time. The product obtained was composed of small particles with smooth surfaces and decreased vapor water permeability. .
In vitro inhibitory activities of urea analogs on bacterial urease
In vitro inhibitory activities of urea analogs on bacterial urease. Chang, Pan Sup; Suh, Byungse; Strockbine, Nancy A.; Kunin, Galvin M. (Health Sci. Cent., Temple Univ., Philadelphia, PA, USA). Arch. Pharmacal Res., 9(3), 163-7 (English) 1986. CODEN: APHRDQ. ISSN: 0253-6269. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Twenty-six urea analogs, most of which have already been approved for human use, were tested for their urease [9002-13-5] inhibitory activity in vitro. Cell-free exts. obtained from a clin. isolate of Proteus mirabilis was used as the source of enzyme. Acetohydroxamic acid [546-88-3] which is a proven potent urease inhibitor but not approved for human use was again shown to be the most active compd. among the tested. Phenacemide [63-98-9], cycloserine [68-41-7], and deferoxamine mesylate [138-14-7] were demonstrated to be moderate inhibitors. Oxytetracycline [79-57-2], trimethoprim [738-70-5], and cefamandole nafate [42540-40-9] revealed a demonstrable antiurease activity, but only at very high concns. The antiurease activity of cycloserine, trimethoprim, and cefamandole was pH dependent; only active at acidic pH. The inhibitory activity of acetohydroxamic acid however was independent of change in pH. H+ concn. plays an important role in urease activity and acidification (pH 5.5) alone eliminates ~65% of the enzymic activity. Adjustment of pH therefore appears to be an important adjunct in reducing urease activity and should always be studied to maximize the efficacy of antiurease compds. under investigation.Except for chemicals metioned above, 42540-40-9 and 61270-58-4 are also used. .
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