Reference

Increase of pineal noradrenaline concentration in rats by desipramine but not fluoxetine: implications concerning the specificity of these uptake inhibitors

Increase of pineal noradrenaline concentration in rats by desipramine but not fluoxetine: implications concerning the specificity of these uptake inhibitors. Fuller, Ray W.; Perry, Kenneth W. (Lilly Res. Lab., Eli Lilly and Co., Indianapolis, Indiana, USA). J. Pharm. Pharmacol., 29(11), 710-11 (English) 1977. CODEN: JPPMAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Pineal gland noradrenaline [51-41-2] concn. was increased by desipramine [50-47-5] (20 mg/kg, i.p.) but was unaffected by fluoxetine [54910-89-3] (20 mg/kg, i.p.). The specificity of these inhibitors of neurotransmitter uptake resides in the uptake pump rather than the substrate.

Pharmacologic effects in man of a specific serotonin-reuptake inhibitor

Pharmacologic effects in man of a specific serotonin-reuptake inhibitor. Lemberger, Louis; Rowe, Howard; Carmichael, Ralph; Oldham, Samuel; Horng, Jong S.; Bymaster, Frank P.; Wong, David T. (Lilly Lab. Clin. Res., Indianapolis, Indiana, USA). Science, 199(4327), 436-7 (English) 1978. CODEN: SCIEAS. ISSN: 0036-8075. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 3 Fluoxetine (Lilly 110140) [54910-89-3] (30 mg capsules) caused a 63 percent inhibition of serotonin [50-67-9] uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no effect on the usual pressor response produced by injections of norepinephrine or tyramine.