Reference

2-(2-Aminoethylamino)-1,2-diphenylethanol derivatives, a new class of topical antiinflammatory agents

2-(2-Aminoethylamino)-1,2-diphenylethanol derivatives, a new class of topical antiinflammatory agents. Fryer, R. Ian; Boris, Alfred; Earley, James V.; Reeder, Earl (Chem. Res. Div., Hoffmann-La Roche Inc., Nutley, N. J., USA). J.There are some reagents like 56-25-7 is used in this study. Med. Chem., 20(10), 1268-72 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 25, 27 Sixteen analogs and derivs. of the title compd. were prepd. by addn. of an amine to a stilbene oxide deriv. Most of the compds. applied topically showed activity in inhibiting cantharidin [56-25-7]-induced inflammation in the ears of rats. An active antiinflammatory, (.+-.)-erythro-2-(2-aminoethylamino)-1,2-diphenylethanol (I) [58733-23-6], reacted with cantharadin to form II [63889-79-2], which had antiinflammatory activity. I reacted with acetone, (used in the antiinflammatory test), to form 2-(2-isopropylideneaminoethylamino)-1,2-diphenylethanol [63889-78-1], which had activity comparable to I. The optical antipodes of I had comparable activity. Structure-activity relations are discussed. .

Pharmacognostical studies on the Chinese crude drugs derived from insects

Pharmacognostical studies on the Chinese crude drugs derived from insects. (II). On Banmao. Inagaki, Kenji; Nunome, Shinyu; Namba, Tsuneo (Res. Inst. Wakan-Yaku, Toyama Med. Pharm. Univ., Toyama 930-01, Japan). Shoyakugaku Zasshi, 37(3), 255-61 (Japanese) 1983. CODEN: SHZAAY. ISSN: 0037-4377. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 12 The compn. of an oriental drug, Banmao, that contained exts. from Mylabris sidae and M. cichorii, was studied by using chromatog. The relative amts. of cantharidin [56-25-7], Me palmitate [112-39-0], Me oleate [112-62-9], etc., in the ether exts. of these insects are described.