CAS No.57808-66-9,Domperidone Suppliers

Products Categories

Pharmaceutical (207)
Others (59)
Organic Chemicals (31)
Reagent (9)
Materials (4)
Plant Extract (3)
(2)
Food Additives (1)

Basic Information

Molecular Structure:
CAS No.:	57808-66-9
Name:	Domperidone
Article Data:	3

Formula:	C₂₂ H₂₄ Cl N₅ O₂
Molecular Weight:	425.918
Synonyms:	5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;Domperidonum;Motilium;
EINECS:	260-968-7
Density:	1.341 g/cm³
Melting Point:	242.5oC
Solubility:	DMSO: >10 mg/mL
Appearance:	white powder
Hazard Symbols:	Xn
Risk Codes:	62-63
Safety:	26-36
PSA:	78.82000
LogP:	3.29110

Synthetic route

: 64928-87-6
1-(3-aminopropyl)benzimidazol-2-one

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 57808-66-9
domperidone

Conditions

Conditions	Yield
With sodium bromide; sodium sulfite In nitromethane for 32h; Solvent; Concentration; Reflux;	51%

: 67-66-3
chloroform

: 108-10-1
4-methyl-2-pentanone

: 62780-89-6
1-(3-Chloropropyl)-1,3-dihydrobenzoimidazol-2-one

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 57808-66-9
domperidone

Conditions

Conditions	Yield
With potassium iodide; sodium carbonate In water	1.3 parts (30%)

...Expand

: 57808-66-9
domperidone

: C22H25N5O3

Conditions

Conditions	Yield
With N,N-dimethyl-formamide for 35h; Irradiation;	50%

: 57808-66-9
domperidone

: domperidone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride for 1h;

: 88-89-1
2,4,6-Trinitrophenol

: 57808-66-9
domperidone

: C6H3N3O7*C22H24ClN5O2

Conditions

Conditions	Yield
In methanol for 0.75h;

: 51-28-5
2,4-Dinitrophenol

: 57808-66-9
domperidone

: C6H4N2O5*C22H24ClN5O2

Conditions

Conditions	Yield
In methanol for 0.75h;

: 1518-16-7
7,7',8,8'-tetracyanoquinodimethane

: 57808-66-9
domperidone

: C12H4N4*C22H24ClN5O2

Conditions

Conditions	Yield
In methanol for 0.75h;

: 84-58-2
2,3-dicyano-5,6-dichloro-p-benzoquinone

: 57808-66-9
domperidone

: C8Cl2N2O2*C22H24ClN5O2

Conditions

Conditions	Yield
In methanol for 0.75h;

: 2,6-dibromoquinone-4-chloroimide

: 57808-66-9
domperidone

: C6H2Br2ClNO*C22H24ClN5O2

Conditions

Conditions	Yield
In methanol for 0.75h;

: 101-38-2
2,6-dichloroquinone-4-chloroimide

: 57808-66-9
domperidone

: C6H2Cl3NO*C22H24ClN5O2

Conditions

Conditions	Yield
In methanol for 0.75h;

Raw Materials

108-10-1

62780-89-6

53786-28-0

67-66-3

Total:212 Page 1 of 6 1 2 3 4 5 6 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 57808-66-9

Chemistry

IUPAC Name: 6-Chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
Molecular Formula: C₂₂H₂₄ClN₅O₂
Molecular Weight: 425.96
EINECS: 260-968-7
Classification Code: Anti-emetic; Antiemetics; Autonomic Agents; Central Nervous System Agents; Dopamine Agents; Dopamine antagonists; Drug / Therapeutic Agent; Gastrointestinal Agents; Human Data; Neurotransmitter Agents; Peripheral Nervous System Agents; Reproductive Effect
Product Categories: Dopamine receptor
Stability: Stable. Incompatible with strong oxidizing agents.
XLogP3: 3.9
H-Bond Donor: 2
H-Bond Acceptor: 3
Rotatable Bond Count: 5
Tautomer Count: 4
Exact Mass: 425.161853
MonoIsotopic Mass: 425.161853
Topological Polar Surface Area: 67.9
Heavy Atom Count: 30
Complexity: 655
Index of Refraction: 1.637
Molar Refractivity: 114.03 cm³
Molar Volume: 317.4 cm³
Polarizability: 45.2×10^-24 cm³
Surface Tension: 55.6 dyne/cm
Density: 1.341 g/cm³
Melting Point: 242.5 °C
Solubility: DMSO: >10 mg/mL
Henry's Law Constant: 6.11E-22 atm-m³/mole at 25 °C
Atmospheric OH Rate Constant: 1.57E-10 cm³/molecule-sec at 25 °C
Vapour Pressure of Domperidone (CAS NO.57808-66-9): 1.15E-14 mm Hg at 25 °C

Uses

Domperidone (CAS NO.57808-66-9) is used as a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	42700ug/kg (42.7mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: ANTIPSYCHOTIC GASTROINTESTINAL: NAUSEA OR VOMITING	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
dog	LD50	oral	> 160mg/kg (160mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
dog	LD50	rectal	> 120mg/kg (120mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 625, 1984.
dog	LD50	subcutaneous	> 160mg/kg (160mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
guinea pig	LD50	intravenous	42900ug/kg (42.9mg/kg)	BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ANTIPSYCHOTIC	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 244, Pg. 130, 1980.
human	LDLo	intravenous	429ug/kg (0.429mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	British Medical Journal. Vol. 288, Pg. 1728, 1984.
human	TDLo	intravenous	714ug/kg (0.714mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	British Medical Journal. Vol. 288, Pg. 1728, 1984.
infant	TDLo	oral	1170ug/kg/1D- (1.17mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Journal of Pediatrics. Vol. 108, Pg. 630, 1986.
man	TDLo	intramuscular	200ug/kg (0.2mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Lancet. Vol. 2, Pg. 1259, 1980.
man	TDLo	oral	234mg/kg/39W- (234mg/kg)	ENDOCRINE: GYNECOMASTIA	Postgraduate Medical Journal. Vol. 67, Pg. 401, 1991.
mouse	LD50	intraperitoneal	> 8gm/kg (8000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
mouse	LD50	intravenous	46500ug/kg (46.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
mouse	LD50	oral	> 8gm/kg (8000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
mouse	LD50	subcutaneous	> 8gm/kg (8000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat	LD50	intraperitoneal	61200ug/kg (61.2mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
rat	LD50	intravenous	41700ug/kg (41.7mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat	LD50	oral	5243mg/kg (5243mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
rat	LD50	rectal	> 250mg/kg (250mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 625, 1984.
rat	LD50	subcutaneous	> 8gm/kg (8000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 3991, 1980.
women	TDLo	intravenous	600ug/kg/1D (0.6mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Lancet. Vol. 2, Pg. 385, 1985.
women	TDLo	intravenous	1mg/kg (1mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	British Medical Journal. Vol. 289, Pg. 1579, 1984.
women	TDLo	rectal	7200ug/kg/30H (7.2mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Journal of Pediatrics. Vol. 105, Pg. 852, 1984.

Safety Profile

Poison by intravenous and intraperitoneal routes. Human systemic effects by intravenous and intramuscular routes: eye effects, convulsions, muscle spasms and cardiac arrhythmias. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x.
Hazard Codes: Harmful Xn
Risk Statements: 62-63
R62: Risk of impaired fertility.
R63: Possible risk of harm to the unborn child.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany of Domperidone (CAS NO.57808-66-9): 3

Specification

Domperidone (CAS NO.57808-66-9), its Synonyms are 2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)- ; 2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro- ; 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone ; Domperidonum ; Motilium . It is white powder.