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Detail of "57808-66-9"

  • CAS Number:
  • 57808-66-9
  • Name:

  • Domperidone

  • Molecular Structure:
  • Formula:
  • C22 H24 Cl N5 O2
  • Molecular Weight:
  • 425.92
  • Synonyms:
  • 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;Domperidonum;Motilium;
  • EINECS:
  • 260-968-7
  • Density:
  • 1.341 g/cm3
  • Solubility:
  • DMSO: >10 mg/mL
  • Appearance:
  • white powder
  • Hazard Symbols:
  • HarmfulXn
  • Risk Codes:
  • 62-63
  • Safety:
  • 26-36 Details
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CAS No.57808-66-9 DomperidoneCompetitive Product

C22H24ClN5O2

Supplier:shandong zhongke taidou chemical co.,ltd [ China (Mainland)]

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CAS No.57808-66-9 Domperidone

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CAS No.57808-66-9 Domperidone

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CAS No.57808-66-9 Domperidone

  Appearance:White powder

Domperidone Name:Domperidone,Motilium Molecular formular:C22H24ClN5O2 Molecular weight:425.9 The solution in clear

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CAS No.57808-66-9 Domperidone

Domperidone is an antidopaminergic drug .The medication increases movement through the digestive system. It is used to treat symptoms of stomach disorders. It may also be used to prevent nausea and vomiting caused by certain medications.

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CAS No.57808-66-9 Domperidone

Name:Domperidone,Motilium Molecular formular:C22H24ClN5O2 Molecular weight:425.9 CAS:57808-66-9 Appearance:White powder The solution in clear and not more inensely coloured than reference solution Y6 Related substance: Total impurity≤0.5%,individual impurity≤0.25% Loss o

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CAS No.57808-66-9 Domperidone

Product Name: Domperidone Chemical Name: Motilium,4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl) propyl]piperidine Molecular Formula: C22H24ClN5O2 Molecular Weight: 425.9 CAS No.: 57808-66-9 EINECS No.: 260-968-7Melting Point : 244-248℃ Appearance: White

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Domperidone is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting. It has also been used to stimulate lactation.

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CAS No.57808-66-9 Domperidone

Chemical Name: DOMPERIDONE CAS No. 57808-66-9 Molecular Formula: C22H24ClN5O2 Formula Weight: 425.91 Property solubility : DMSO: >10 mg/mL form : solid color : white Safety Hazard Codes : Xn Risk Statements : 62-63 Safety Statements

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Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

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Reference

Effects of pimozide and domperidone administration on prolactin levels in neonatally estrogenized female rats
Effects of pimozide and domperidone administration on prolactin levels in neonatally estrogenized female rats. Aguilar, E.; Lopez, F.; Pinilla, L.; Bellido, C.; Vaticon, M. D. (Fac. Med., Univ. Cordoba, Cordoba 14080, Spain). Rev. Esp. Fisiol., 41(2), 183-6 (English) 1985. CODEN: REFIAS. ISSN: 0034-9402. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 The effects of 2 dopaminergic blockers, pimozide [2062-78-4] and domperidone [57808-66-9], on prolactin [9002-62-4] secretion were investigated in adult female rats treated neonatally with estrogens (100 mg estradiol [50-28-2] as the benzoate s.c. on day 1). These rats showed hyperprolactinemia (556 mg/L vs. 57.7 in control) and treatment with pimozide or domperidone failed to increase prolactin levels in the adult age. Apparently, the hyperprolactinemia in neonatally estrogenized female rats is produced by loss of the dopaminerigc inhibition on prolactin secretion, so that the pharmacol. blockade of dopaminergic receptors is uneffective. Dopamine levels in hypothalamus were similar in control and estrogenized females suggesting that failure in dopaminergic inhibition is due to a decrease in dopamine secretion to portal vessels.
Side effects of drugs stimulating prolactin secretion on the behavior of male rats
Side effects of drugs stimulating prolactin secretion on the behavior of male rats. Drago, F.; Scapagnini, U. (Med. Sch., Univ. Catania, Catania, Italy). Arch. Int. Pharmacodyn. Ther., 276(2), 271-8 (English) 1985. CODEN: AIPTAK. ISSN: 0003-9780. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The behavioral effects of drugs stimulating prolactin (PRL) [9002-62-4] secretion were studied in male rats. Acquisition of active avoidance behavior was facilitated by short- (SHPRL) and long-term hyperprolactinemia (LHPRL) induced by pituitary homografts under the kidney capsule. Dopamine antagonists, such as haloperidol [52-86-8] and bromoperidol [10457-90-6], though causing hyperprolactinemia, suppressed the acquisition of active avoidance behavior. Sulpiride [15676-16-1] was not effective in this respect. SHPRL facilitated and LHPRL inhibited sexual behavior of male rats. Haloperidol, but not sulpiride, suppressed sexual capacity of these animals. Sulpiride and domperidone [57808-66-9] but not haloperidol, increased locomotor activity of male rats. Differences in the behavioral effects of dopamine antagonists may depend on their capacity to compete with PRL at the central level.
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